Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Sachan, Anupam K; Gupta, Amit; Ansari, Anees A.

doi:10.22270/jddt.v8i5.1850

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The quantity of medicament encapsulated per unit weight of the nanoparticles is determined after the release of running medicament and solid lipids from the gel medium. The graphical representation is given below 23 .…”

Section: Determination Of Temmentioning

confidence: 99%

Untitled

2021

IJPSR

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The objective of the research work was to design NLCs gel of Acitretin and perform an in-vitro evaluation of different formulations. FTIR and DSC studies revealed that there was no interaction between drug and polymer and with the respective surfactant. A new generation of NLCs consisting of a lipid matrix with a special nanostructure has been developed. These nanostructures improve drug loading and firmly incorporates the drug during storage. The purpose of this study was to prepare Acitretin-loaded NLCs gel effective for topical delivery of Acitretin by using the Hot Homogenization method. Stearic acid as solid lipid, Oleic acid as liquid lipid combination of two types of surfactant: Tween 80 and Sodium lauryl sulphate (SLS) were used to stabilize NLCs dispersion. Physiochemical properties of NLCs gel such as particle size, TEM, entrapment efficiency, and in-vitro release studies were investigated. The formulation in which a combination of ionic and non-ionic surfactant was used to demonstrated good entrapment efficiency, sustained invitro release profile. In-vitro release study revealed the biphasic release pattern of NLCs gel system. Results suggested that the combination of two surfactants produces a stable system with good entrapment efficiency and desired particle size. Act NLCs gel formulation with skin targeting may be a promising carrier for topical delivery Acitretin.

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Section: Determination Of Temmentioning

confidence: 99%

Untitled

2021

IJPSR

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Nitazoxanida: aspectos gerais, sistemas de liberação e potencial de reposicionamento da molécula

Lira

Sousa

Brito

et al. 2021

RSD

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A nitazoxanida (NTZ) é um fármaco empregado no tratamento de infecções virais e parasitárias devido ao seu mecanismo de ação ativar processos de morte celular. Entretanto, apresenta baixa biodisponibilidade oral, restringindo a sua utilização na terapêutica, com isso, novos sistemas de liberação são necessários para melhor absorção in vivo. O objetivo desta revisão narrativa foi abordar aspectos referentes a características físico-químicas da molécula de Nitazoxanida e seu potencial de reposicionamento. Foram realizadas buscas nas bases de dados Pubmed, Lilacs e Science Direct, selecionados artigos em inglês e português, cruzando os descritores “Nitazoxanida”, “caracterização” e “formulação” combinados entre si. Evidências científicas descrevem a NTZ como uma molécula de baixo peso molecular, melhor absorvida em pH ácido, que sofre desacetilação originando seu metabólito ativo, a Tizoxanida. Estudos relatam sua aplicação frequentemente em doenças por Giardia lamblia, Entamoeba histolytica e Cryptosporidium parvum, além de infecções por protozoários, helmintos, bactérias gram negativas e positivas e possuir propriedades antivirais, estando relacionado a sua descoberta recente na COVID-19, inclusive associada a outros fármacos. Assim, sistemas como lipossomas, nanopartículas, microesferas, comprimidos de liberação controlada foram relatados como potencializadores veículos na liberação do fármaco, além de possibilitar melhoria nos seus aspectos físico-químicos. Portanto, a NTZ representa uma molécula com grande potencial de aplicação e reposicionamento, abrangendo inúmeras possibilidades.

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Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System

Sachan¹,

Singh²,

Devi³

2021

RJPT

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Microspheres carrier system made from natural or synthetic polymers used in sustained release drug delivery system. The present study involves formulation and evaluation of floating microspheres of Curcumin for improving the drug bioavailability by prolongation gastric residence time. Curcumin, natural hypoglycemic agent is a lipophilic drug, absorbed poorly from the stomach, quickly eliminated and having short half-life so suitable to formulate floating drug delivery system for sustained release. Floating microspheres of curcumin were formulated by solvent evaporation technique using ethanol and dichloromethane (1:1) as organic solvent and incorporating various synthetic polymers as coating polymer, sustain release polymers and floating agent. The final formulation were evaluated various parameters such as compatibility studies, micrometric properties, In-vitro drug release and % buoyancy. FTIR studies showed that there were no interaction between drug and excipients. The surface morphology studies by SEM confirmed their spherical and smooth surface. The mean particles size were found to be 416-618µm, practical yield of microspheres was in the range of 60.21±0.052% - 80.87±0.043%, drug entrapment efficiency 47.4±0.065% - 77.9±0.036% and % buoyancy 62,24±0.161% - 88.63±0.413%. Result show that entraptmency increased as polymer (Eudragit RS100) conc. Increased. The drug release after 12 hrs. was 72.13% - 87.13% and it decrease as a polymer (HPMC, EC) concentration was decrease.

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Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Cited by 3 publications

References 7 publications

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Nitazoxanida: aspectos gerais, sistemas de liberação e potencial de reposicionamento da molécula

Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System

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