Formulation and Characterization of Odt Using Different Co-Process Containing Daclatsvir: In Vitro and in Vivo Pharmacokinetics Study on Healthy Volunteers for Hepatitis C Treatment
Abstract:Objective: This study aimed to prepare and evaluate oral disintegrating tablets (ODTs) of Daclatasvir dihydrochloride (DCV) using different co-processed excipients to enhance drug dissolution and improve oral bioavailability for the treatment of hepatitis C infection.
Methods: Ten Daclatasvir-ODTs formulae were prepared using co-processed excipients via direct compression. The prepared formulae were evaluated according to taste masking, weight variation, thickness, friability, hardness, drug content, and wetti… Show more
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