Formulation and Characterization of Rivastigmine Loaded Solid Lipid Nanoparticles

Abstract

In the present study, we explored the potential of Rivastigmine loaded solid lipid nanoparticle (SLN), as a new formulation in improving the bioavailability of Antialzheimer drug Rivastigmine which otherwise reported with poor bioavailability. The "Micrioemulsion based method" was adopted for preparation of SLN. A 3 2 full factorial experiment was designed to study the effect of independent variables such as lipid, surfactant and co-surfactant composition. The formulations were lyophilized to get free flowing powder. The mean particle size of SLN measured to be 137 -1300 nm with PDI value of 0.590 -1.279, and zeta potential value of -3.27 to -27.31 mV was observed which indicates SLN formulations found to more stable. The entrapment efficiency was estimated to be 92.82 -99.80%. SEM study shows SLN in spherical as well as irregular in shape. DSC and FTIR results also confirmed the molecular encapsulation of drug in the lipid matrix. The in-vitro release study shows that all formulations followed Higuchi's Classical Diffusion Model which implies that developed formulations have a potential to deliver the drug in controlled release manner. These finding explore the potential of proposed SLN of rivastigmine formulation as an alternative drug delivery system in improving bioavailability of Rivastigmine.

Optimization, Characterization and in Vivo Study of Rivastigmine Tartrate Nanoparticles by Using 22 Full Factorial Design for Oral Delivery

“…The data of FTIR were similar to results obtained in work done by Ravi et. al 2017 and Kulkarni 2018 [4,23].…”

“…Our result of optimized formulation supports the findings similar to that of Kulkarni et. al, 2018 [23]. Parameters are expressed as mean±SD, n=3.…”

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“…The entrapment efficiency of Rivastigmine SLNS was estimated by the centrifugation method, at 1500 rpm for 30 minutes. The untrap Rivastigmine was determined by UV spectrophotometer (Shimadzu UV 1800) at 221nm and calculated by the following formula % Entrapment efficiency = Total amount of drug -Free dissolved drug Total Amount of Drug: % Entrapment efficiency of Rivastigmine SLNS was found to be 93.26-99.80% 51 .…”

“…In-vitro dissolution studies were carried out by USP apparatus type II, using 900ml phosphate buffer pH 7.4 and temperature 37±0.5°C. The rotation speed was 50rpm and samples were analyzed by UV spectrophotometer (Shimadzu UV 1800) 51 .…”