2017
DOI: 10.1016/j.jddst.2017.08.001
|View full text |Cite
|
Sign up to set email alerts
|

Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
11
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 16 publications
(11 citation statements)
references
References 62 publications
0
11
0
Order By: Relevance
“…In the present study, the in vitro release was carried out at two different pH values. Aqueous media consist of a mixture of 78% deionized water, 20% methanol, and 2% Tween-80 with a pH similar to that of the skin (5.5) and phosphate buffer pH 7.4, which simulates the natural wound environment (pH =7.15–8.90) 25…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In the present study, the in vitro release was carried out at two different pH values. Aqueous media consist of a mixture of 78% deionized water, 20% methanol, and 2% Tween-80 with a pH similar to that of the skin (5.5) and phosphate buffer pH 7.4, which simulates the natural wound environment (pH =7.15–8.90) 25…”
Section: Resultsmentioning
confidence: 99%
“…The formulation was placed into the donor chamber. Dissolution test was carried out in two different media: phosphate buffer (pH 7.4), which simulates the natural wound environment (pH =7.15–8.90),6,25 and an aqueous medium that consists of a mixture of 78% deionized water, 20% methanol, and 2% Tween-80 with pH adjusted to 5.5, which is similar to the pH of the skin. At specific time intervals (namely 0.5, 1, 2, 3, 4, 6, 8, 12, and 24 hours), aliquots of 1 mL were withdrawn and immediately restored with the same volume of fresh dissolution media.…”
Section: Methodsmentioning
confidence: 99%
“…The PDI was ~0.2 for both PPD-N and the bare formulations, indicating a narrow, monodispersed distribution. The negative charges on the surface of the NLC provided formulations with good stability [ 36 ]. The results of EE and DL percentages indicated that the PPD-NS has a good DL capacity, which are essential parameters in terms of drug delivery.…”
Section: Discussionmentioning
confidence: 99%
“…Tissue scaffolds revealed a three-dimensional (3D) porous structure with ∼100−200 μm pore size, low rate of degradation, and good mechanical strength along with a desired sustained drug release profile. 108 A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay performed on L929 mouse fibroblast cells showed that the prepared tissue scaffolds exhibited a cell viability of 75%.…”
Section: Lipid-based Nanocarriers For Diabeticmentioning
confidence: 99%