Formulation and development of moxifloxacin nanoemulsion for ophthalmic delivery

Abstract

Nano emulsions formulated for the ocular drug delivery have a good scope in pharmaceutical products due to the transparency at enlarged droplet volume fraction, advanced rate of bioavailability and improved shelf life. In this study we aim to prepare & evaluate moxifloxacin nano emulsion of for ocular delivery that will result with improved drug retention in cornea, sustained release will be achieved and dosing frequency will be reduced as compared with conventional products. Drug identification was done by UV FTIR, melting point and solubility. Nano emulsion were prepared by standard procedure with minor modifications. Particle size was found around 380 nm by Malvern analyser. SEM showed droplets of spherical shape and size 300 nm. % entrapment was 81 %. Microscopy also showed drops oval to spherical in shape. Marketed formulation released 100 % within 30 min where as optimized nano emulsion was released in sustained manner for more than 6 hrs. Thus it can be concluded that designed formulation can be able to improve drug activity.