Formulation and development of Silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis

Shrotriya, Shilpa; Vidhate, Bhagvat; Shukla, Manasi S.

doi:10.1016/j.jddst.2017.07.006

Cited by 25 publications

(17 citation statements)

References 38 publications

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“…FTIR studies of AM (pure drug) and COF were carried out to evaluate any changes in the principal functional groups of drug and for confirmation of entrapment of drug in lipid. The study was conducted on IR spectrophotometer (Shimadzu, FTIR 8700), in the frequency region of 400 to 4000 cm-1 by the direct sampling method [19].…”

Section: Fourier-transform Infrared Spectroscopy (Ftir) Studiesmentioning

confidence: 99%

Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Devi

Vidyavathi

Suryateja³

2021

JPRI

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Aim: The aim of the present study was to design and evaluate solid lipid nanoparticles of Asenapine maleate (<2% bioavailability) to enhance its oral bioavailability and surface modification for brain targeting. Methods: A modified solvent injection method was used to produce Asenapine maleate loaded solid lipid nanoparticles. A RSM 3-factor, 3-level Box-Behnken design was applied to study the effect of three independent variables, concentrations of lipid (A), drug (B) and surfactant (C) on three dependent variables, particles size (Y1), entrapment efficiency (Y2), and drug release (Y3). 3-D surface response plots were drawn and optimized formulation was selected based on desirability factor. Then it was coated with tween 80 for ease of permeability through blood brain barrier due to intact absorption of solid lipid nanoparticles. Results: The results of coated optimized formulation showed average particle size of 108.9 nm, entrapment efficiency of 78.62%, and in vitro drug release of 98.88±0.102% at 36 hr at pH 7.4. Morphologically, particles were almost spherical in shape with uniform size distribution. Targeting of coated optimized formulation to brain after oral administration was confirmed by fluorescence microscopy studies on male albino wistar strain rats. This research also envisaged that there is a >85% cell viability up to 125µg/ ml concentration of coated solid lipid nanoparticles by MTT assay. Conclusion: Thus, the current study successfully designed, developed an optimized SLN formulation of Asenapine maleate using a 3-factor, 3-level Box-Behnken design for brain targeting to treat Schizophrenia by bypassing the first pass metabolism with enhanced oral bioavailability.

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Section: Fourier-transform Infrared Spectroscopy (Ftir) Studiesmentioning

confidence: 99%

Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Devi

Vidyavathi

Suryateja³

2021

JPRI

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“…Shrotriya S.N. et al [ 36 ] designed SB-loaded solid lipid nanoparticle-enriched Carbopol gel whose topical application appears efficient in dinitrochlorobenzene-induced ICD in mice. Szekalska et al [ 62 ] tested an alginate-based HG, considered a suitable drug carrier for this kind of application due to its antiallergic and anti-inflammatory activities, incorporated with cynaroside (CYN) [a luteolin (LT) derivative].…”

Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning

confidence: 99%

“…Comparable outcomes (and then considerations) have been discussed by Shrotriya et al in a research work where they used SB-loaded solid lipid nanoparticles incorporated into a Carbopol HG to afford the composite HG formulation that provided a controlled release of the bioactive compound and a superior therapeutic efficacy in a model of skin inflammation with respect to the HG formulation containing free SB [ 36 ]. Overall, these works performed on SB demonstrate the vast potential of the nanocomposite HGs as delivery systems for topical applications.…”

Section: Hydrogels Projected For Topical Applicationsmentioning

confidence: 99%

“…In regard to the HG-based materials, Balestrin L.A. and co-workers proposed a delivery system composed of a nanoemulsion of Achyrocline satureioides crude ethanolic extract (80% v / v ) and a Carbopol ® Ultrez 20 matrix as gelling agent [ 36 ]. The HG system was obtained by the spontaneous emulsification (oil-in-water) method and was intended as topical formulation for protection of the UV-induced skin damage.…”

Section: Hydrogels Projected For Topical Applicationsmentioning

confidence: 99%

“…Also in that case, the composite HG system turned out to be more effective in comparison to the SB-plain HG, specifically in protecting skin damage induced by UV irradiation. les 2020, 25, 3254 omparable outcomes (and then considerations) have been discussed by Shro rch work where they used SB-loaded solid lipid nanoparticles incorporated into ord the composite HG formulation that provided a controlled release of the bioac a superior therapeutic efficacy in a model of skin inflammation with resp lation containing free SB [36]. Overall, these works performed on SB demo tial of the nanocomposite HGs as delivery systems for topical applications.…”

Section: Hydrogels Containing Other Flavonoidsmentioning

confidence: 99%

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Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

et al. 2020

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This review deals with hydrogels as soft and biocompatible vehicles for the delivery of plant-derived (poly)phenols, compounds with low general toxicity and an extraordinary and partially unexplored wide range of biological properties, whose use presents some major issues due to their poor bioavailability and water solubility. Hydrogels are composed of polymeric networks which are able to absorb large amounts of water or biological fluids while retaining their three-dimensional structure. Apart from this primary swelling capacity, hydrogels may be easily tailored in their properties according to the chemical structure of the polymeric component in order to obtain smart delivery systems that can be responsive to various internal/external stimuli. The functionalization of the polymeric component of hydrogels may also be widely exploited to facilitate the incorporation of bioactive compounds with different physicochemical properties into the system. Several prototype hydrogel systems have been designed for effective polyphenol delivery and potential employment in the treatment of human diseases. Therefore, the inherent features of hydrogels have been the focus of considerable research efforts over the past few decades. Herein, we review the most recent advances in (poly)phenol-loaded hydrogels by analyzing them primarily from the therapeutic perspective and highlighting the innovative aspects in terms of design and chemistry.

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The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections

Ryan

Patel

Ratrey

et al. 2023

Drug Deliv. and Transl. Res.

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Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain bacteriocin produced by Lactococcus lactis that is active against S. aureus including MRSA strains. Previously, poor physicochemical properties of the peptides were overcome by the encapsulation of lacticin 3147 into solid lipid nanoparticles. Here, a lacticin 3147 solid lipid nanoparticle gel is proposed as a topical treatment for S. aureus and MRSA wound infections. Initially, lacticin 3147’s antimicrobial activity against S. aureus was determined before encapsulation into solid lipid nanoparticles. An optimised gel formulation with the desired physicochemical properties for topical application was developed, and the lacticin-loaded solid lipid nanoparticles and free lacticin 3147 aqueous solution were incorporated into separate gels. The release of lacticin 3147 from both the solid lipid nanoparticle and free lacticin gels was measured where the solid lipid nanoparticle gel exhibited increased activity for a longer period (11 days) compared to the free lacticin gel (9 days). Both gels displayed potent activity ex vivo against S. aureus-infected pig skin with significant bacterial eradication (> 75%) after 1 h. Thus, a long-acting potent lacticin 3147 solid lipid nanoparticle gel with the required physicochemical properties for topical delivery of lacticin 3147 to the skin for the potential treatment of S. aureus-infected chronic wounds was developed. Graphical abstract

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Formulation and development of Silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis

Cited by 25 publications

References 38 publications

Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections

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