Formulation and Development of Sustained Release of Cefixime using Floating Oral In Situ Gelling System

Chaturvedi, Preeti; Manigauha, Ashish

doi:10.52711/0974-360x.2022.00193

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Therefore, in order to address the aforementioned concerns, it was decided to create a novel floating in-situ gelling system of Azithromycin dihydrate with a longer residence period using sodium alginate as the gelling polymer and xanthan gum as the thickening agent. The advantages of the novel sodium alginate based Azithromycin dihydrate floating in situ gelling systems include simplicity of administration due to their liquid form and improved patient compliance [8].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Kumar

2023

Int J Pharm Sci

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Floating Drug Delivery Systems have been used to overcome some of the problems like low oral absorption of drugs with narrow absorption window as it has an advantage of sustained release of drugs over a prolonged period of time. In-situ gels are the novel approach in the context of floating drug delivery systems. The aim of this present study was to develop an oral stomach specific floating in-situ gel of Azithromycin dihydrate. In-situ gelling system was prepared by dissolving different concentrations of polymers like sodium alginate, xanthan gum in the de-ionized water already prepared with sodium citrate at 60°C to 90°C. After the heating with continuous stirring the formulation was cooled below the temperature of 40°C with the addition of certain amount of drug and calcium carbonate which acts as gas generating agent. All the formulations showed pH in the range of 6.1 to 6.7, drug content was found to be in the range of 97.29% to 99.27%. Floating lag time was less than 1 minute for all the formulations and the duration of floatation was more than 24 hours for the combination of polymers. Appearance and measurement of water uptake by the gel was also good. Stability studies were also done and was found to be at normal phase at different temperatures and at interval of times. Although, F9 showed the maximum properties of an in-situ gel with increased gastric retention time with low slowly release of the drug. Drug release was found to be decreasing as the concentration of polymer increases. However, it was concluded that the in-situ gelling system of Azithromycin dihydrate could be prepared in various concentrations of different polymers and the combination of polymers to increase the patient compliance and reduction in the frequency of dosing of the drug with the increased gastric residence time for the drug in the stomach.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Kumar

2023

Int J Pharm Sci

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Formulation and Evaluation of Ion Activated In-Situ Gelling Ophthalmic Solution containing Brimonidine Tartrate using 32 Factorial Design

M. Rajamanya,

S. Thorat,

H. Hosmani

et al. 2024

RJPT

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The objective of the current work is to develop an ion activated in situ gel for treatment of Glaucoma with Brimonidine Tartrate. As conventional eye drops exhibit the demerits of poor bioavailability, naso-lachrymal drainage and rapid pre-corneal elimination, it was proposed that ion activated ophthalmic in situ gel formulation approach can be used to address these issues. The gels were formulated using 32 factorial design by cold method using sodium alginate as gelling agent in the concentration of 1%, 1.25% and 1.5 %. HPMC K4M and Carbobol 971 P were used as mucoadhesive agent to increase ocular residence. The evaluation of the prepared formulations was done for appearance, gel strength, mucoadhesion, viscosity, gelation, pH, drug content, sterility and in vitro diffusion. The ocular irritancy test was done by HET CAM test as well as the results show that the prepared in situ gel formulation exhibit sustained drug release up to 6 hours with excellent mucoadhesion which can achieve the objective of better ocular bioavailability.

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Formulation and Development of Sustained Release of Cefixime using Floating Oral In Situ Gelling System

Cited by 2 publications

References 13 publications

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Formulation and Evaluation of Ion Activated In-Situ Gelling Ophthalmic Solution containing Brimonidine Tartrate using 32 Factorial Design

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