Formulation and drying of miconazole and itraconazole nanosuspensions

Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?

“…In addition, all suspensions had zeta potentials (absolute) less than 20 mV when HPC was used alone; yet, PB and IBU suspensions did not show significant aggregation. In fact, earlier work 50 suggested that the adsorbed polymer layer can reduce surface charge, and suspensions even with less than 20 mV (absolute) zeta potential could be stable via steric mechanism 50,51 . Thus, zeta potential alone may not adequately characterize the stability of all drug nanosuspensions stabilized with combined stabilizers 31,51 and such results must be interpreted with caution 51 .…”

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation

“…2). Because a combination of two or more stabilizers, such as a steric stabilizer and an electrostatic stabilizer, could efficiently promote size reduction to the nanometer range (Niwa et al, 2011) and regulate the zeta potential to an appropriate value (Cerdeira et al, 2013), the combination of TPGS and soya lecithin or HP-b-CD as co-stabilizers were investigated in the present study. Notably, the inhomogeneous precipitation generated with HP-b-CD alone before homogenization disappeared after combining HP-b-CD with TPGS, indicating that this stabilizer combination for myricetin nanosuspensions was superior to HPb-CD alone.…”

Fabrication of drug-loaded edible carrier substrates from nanosuspensions by flexographic printing

“…However, formation of amorphous materials can occur after drying of nanosuspensions due to stronger interactions between the drug and stabilizer molecules (Kayaert and Van den Mooter, 2012). Spray-drying and freeze-drying of nanosuspensions have shown to lower the peak intensities in the XRD diffractograms and induce differences between the pure material and the mixtures with excipients (Cerdeira et al, 2013;Liu et al, 2011). The XRD analysis herein could not confirm the presence of amorphous state in the printed formulations.…”

“…Several stabilizing agents, such as hydroxypropyl cellulose (HPC) (Cerdeira et al, 2010(Cerdeira et al, , 2013Chung et al, 2012;Figueroa and Bose, 2013;Lee 2003), polyvinylpyrrolidone (PVP) (Ali et al, 2011;Cerdeira et al, 2010;Ghosh et al, 2011), poloxamers (Cerdeira et al, 2010(Cerdeira et al, , 2013George and Ghosh, 2013;Ghosh et al, 2011;Liu et al, 2011;Nakarani et al, 2010;Van Eerdenbrugh et al, 2008c), D-a-tocopherol polyethylene glycol succinate (TPGS) (George and Ghosh, 2013;Ghosh et al, 2011a,b) and others have been used in the production of nanosuspensions by wet ball-milling technique. The addition of ionic surfactants has also been investigated in several studies (Cerdeira et al, 2010(Cerdeira et al, , 2013Figueroa and Bose, 2013;George and Ghosh, 2013;Ghosh et al, 2011;Van Eerdenbrugh et al, 2008c).…”