Formulation and evaluation of aceclofenac-loaded nanoparticles by solvent evaporation method

Rathore, Suman Kumar; Pathak, Brajesh

doi:10.5958/0975-4377.2020.00039.7

Research Journal of Pharmaceutical Dosage Forms and Technology

2020

DOI: 10.5958/0975-4377.2020.00039.7

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Formulation and evaluation of aceclofenac-loaded nanoparticles by solvent evaporation method

Suman Kumar Rathore¹,

Brajesh Pathak²

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Cited by 3 publications

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Formulation of Nano-sized dispersion from Calendula Officinalis: A Natural gateway to preparation of a Hair Dye

Louis

Rashad

2023

RJPT

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Hair dyes have been used to cover gray hair or to give an appealing look. In the present study, the extract of Calendula Officinalis was used in preparing a hair dye. This represents a natural gateway in development of hair dye to avoid damage caused by synthetic dyes. The yellow coloring principle of the extract, Calendulin, was converted into nano-sized formula ensuring hair fiber penetration. Nine formulae were prepared by solvent evaporation technique, based on a 32 factorial design using Design Expert® program, independent variables being: speed and time of homogenization; three levels: low, medium and high. Polyvinyl alcohol (0.5% w/v) was used as stabilizing agent. Formulae were evaluated by determination of Zeta size, potential and polydispersity index. Response surface modeling enabled choosing the optimal formula (least particle size, polydispersity index and highest zeta potential), which was evaluated by transmission electron microscopy and dyeing effect as a gel containing 0.5% Carboxymethyl cellulose. F7, produced by operating the homogenizer at 26000rpm for 10 minutes proved to be optimal which succeeded to dye white hair and lighten up the black hair as evidenced by optical microscope images. Hence it was recommended to use F7 in covering the white hair.

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Formulation of Nano-sized dispersion from Calendula Officinalis: A Natural gateway to preparation of a Hair Dye

Louis

Rashad

2023

RJPT

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Efavirenz cocrystals with Ascorbic acid: A Strategy for Polymorphic Modification and improvement of Dissolution properties

S. Gurav,

S. Kulkarni

2024

RJPT

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The objective of this research was to improve the solubility and dissolution rate of Efavirenz (EFA), a BCS II drug utilized for HIV infection treatment, by cocrystallization with ascorbic acid (AA). An in silico analysis indicated that EFA and AA exhibited physical interaction and compatibility. EFA exists in two polymorphic forms, I and II, with varying crystalline habits, where polymorph II presents better solubility and dissolution rate. Cocrystals were prepared using the solvent evaporation method by varying AA concentration and temperature. FTIR and NMR analysis confirmed the absence of chemical interaction between EFA and AA. Increasing AA concentration and temperature significantly increased the saturation solubility. DSC, XRD and SEM analysis revealed a shift in the endothermic peak of EFA, change in intensity with 2θ values, and modified surface morphology respectively. This also confirmed a polymorphic structure change in the cocrystals due to high heating rates and maximum crystallization rate. The dissolution rate of the cocrystals was enhanced by the optimized batch, which contained an intermediate concentration of AA and was subjected to the highest temperature condition, and the data fitted well with the Higuchi model of kinetics. The stability of the cocrystals was also evaluated by accelerated stability testing to determine the percentage of drug content. Thus, cocrystallization with AA proved to be a suitable approach for enhancing the dissolution characteristics and polymorphic modification of BCS II drugs, such as EFA.

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Formulation Development of Tranexamic Acid loaded Transethosomal Patch for Melasma

Shaji

Parab

2022

RJPDFT

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Nanotechnology based drug delivery systems are employed to overcome the hitches associated with conventional therapies. Melasma is a chronic, acquired, therapeutically challenging, universally relapsing hyperpigmentation disorder that causes greyish-brown spots on the skin, mainly on the face. Tranexamic acid (TXA) is a newer medication used to treat melasma that can be administered topically as well as orally. TXA has an oral bioavailability of 30-50%. The current study aimed to create a transethosomal (TEL) patch, for transdermal delivery of TXA for the treatment of melasma as an alternative to the oral route's hindrance. The cold technique was used to prepare TEL. They are composed of phospholipid (Phospholipon 90G), ethanol, water, and an edge activator (sodium cholate). Drug excipient compatibility study was done using Differential scanning colorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy techniques. TEL batches were further characterized based on particle size (PS) and entrapment efficiency (EE). The optimized batch's PS and EE were found to be 72 nm and 94%, respectively. The average zeta potential was -16 mV, indicating a stable formulation. Vesicular morphology was monitored by Scanning electron microscopy (SEM) analysis. The in vitro and ex vivo release of TXA was evaluated by Franz diffusion study and showed the release of about 93.97% over the period of 24 hrs, which was better than that of a conventional topical cream. All of the above findings showed that TEL may be a good carrier alternative for delivery of TXA into deeper layers, and hence good for treating melasma.

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Formulation and evaluation of aceclofenac-loaded nanoparticles by solvent evaporation method

Cited by 3 publications

References 0 publications

Formulation of Nano-sized dispersion from Calendula Officinalis: A Natural gateway to preparation of a Hair Dye

Formulation of Nano-sized dispersion from Calendula Officinalis: A Natural gateway to preparation of a Hair Dye

Efavirenz cocrystals with Ascorbic acid: A Strategy for Polymorphic Modification and improvement of Dissolution properties

Formulation Development of Tranexamic Acid loaded Transethosomal Patch for Melasma

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