Formulation and evaluation of antibacterial gel containing ethanol extract of thorns of Bombax ceiba

Abstract

Purpose Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes Methods Agar well diffusion method were employed for the purpose. Results Gel formulation of different concentration of extract were formulated that is 2%, 4%, 6% and 8% respectively and antibacterial activity of the gels were measured against the bacteria Staphylococcus aureus and Propionibacterium acnes. In this clindamycin gel was used as the standard for comparative analysis. From evaluation results it was concluded that formulation of 8% showed better antibacterial activity as compared to other formulated preparations. In addition to this, evaluation of gel formulations was performed considering various parameters which were pH, appearance, viscosity, spreadibility and homogeneity and the result were calculated. Conclusion The ethanol thorn’ extract of Bombax ceiba possess good antibacterial property against the Staphylococcus aureus and Propionibacterium acnes. It also contains various phytoconstituents which may be helpful in various health related problems.