Formulation and Evaluation of Antibacterial Herbal Mouthwash Against Oral Disorders

Ahmad, S Rehan; Sinha, Saloni; Ojha, Smriti; Chadha, Hina; Aggarwal, Babita; Ajeet,; Jain, SeemaMahor; Meenu,

doi:10.35652/igjps.2018.3740

Cited by 18 publications

(8 citation statements)

References 5 publications

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“…Mouthwashes containing plant based preparations may mask malodour and provide a pleasant flavor (Ahmad et al, 2018). The oral cavity contains many habitats (teeth, gingival sulcus, tongue, palates, and tonsils) providing space for the colonization by various microorganisms such as bacteria, fungi and viruses.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activities of mouthwashes obtained from various combinations of Elettaria cardamomum Maton., Lavandula angustifolia Mill. and Salvia triloba L. essential oils

Karadağ

İpekçi²,

Yağcılar³

et al. 2020

Natural Volatiles and Essential Oils

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The aim of this present study was to evalute Elettaria cardamomum (L.) Maton., Lavandula angustifolia Mill. and Salvia fruticosa Mill. essential oils in mouthwashes formulated with different combinations such as 0.1/0.25/0.1; 0.2/0.25/0.1; 0.3/0.1/0.1 in 10 mL (v/v), and their in vitro antibacterial activity performance. The characterization of the main essential oil components was performed by GC-FID and GC/MS analyses. The antimicrobial evaluation was performed by using the disc diffusion method against human pathogenic Staphylococcus aureus ATCC 6538, Escherichia coli NRLL B-3008, Bacillus cereus ATCC 14579, and Salmonella typhii (clinical isolate), respectively. In the present study, among the tested bacteria S. typhii was the most sensitive, while B. cereus and E. coli were the most resistant pathogens in the applied mouthwash formulations. The essential oil combination containg mouthwash formulations can be used as a functional naturals based cosmetics.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial activities of mouthwashes obtained from various combinations of Elettaria cardamomum Maton., Lavandula angustifolia Mill. and Salvia triloba L. essential oils

Karadağ

İpekçi²,

Yağcılar³

et al. 2020

Natural Volatiles and Essential Oils

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show abstract

“…This process was carried out continuously for 6 days (3× cycles) and then transferred to room temperature. During these processes, physical conditions were observed, especially changes in consistency, color, smell, and appearance (Ahmad et al, 2018).…”

Section: Quality Control Tests Of the Ecgle-based Mouthwash Formulationmentioning

confidence: 99%

In vitro cytotoxicity of ethanolic extract of the leaf of Calotropis gigantea from Ie Jue Geothermal Area, Aceh-Indonesia, and its mouthwash formulation against dental pulp cells

Setya¹,

Idroes²,

M.³

et al. 2022

J App Pharm Sci

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The ethanolic Calotropis gigantea leaf extract (ECGLE) from Ie Jue geothermal area, Aceh-Indonesia, and ECGLEbased mouthwash formulation has been prepared. The formulation was prepared with various extract concentrations ranging from 0 to 25% of ECGLE. Both the extract and formulation were evaluated for antibacterial and in vitro cytotoxic activity in order to determine their potential medicinal value in the oral cavity. Antibacterial tests were carried out against Gram-negative bacteria (Porphyromonas gingivalis), Gram-positive bacteria (Solobacterium moorei), and a mix of both Gram-negative and Gram-positive bacteria (P. gingivalis + S. moorei). The cytotoxic activity was evaluated against human dental pulp primary cells (hDPPC) by calorimetric assay using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide. All formulations passed the stability test with a pH of 5.35-5.92. Antibacterial activity testing revealed that the higher the ECGLE concentration, the more effective it is against bacteria. In comparison with other formulations, formulation-3 containing 3 gr of ECGLE demonstrated the highest activity. The minimum inhibitory concentration (MIC) value and % inhibition of formulation-3 against P. gingivalis, S. moorei, and a mix of both bacteria were 0.089, 0.075, and 0.083 µg/ml and 88.924%, 90.691%, and 89.72%, respectively. The cytotoxicity activities (IC 50 ) for both ECGLE and a formulation containing ECGLE were 6.44 and 0.27 gr/ml, respectively. The ability of cells to undergo apoptosis showed a strong correlation between cell viability and the ECGLE extract (R 2 = 0.973) as well as ECGLE-based mouthwash formulation (R 2 = 0.897). The greater the concentration of ECGLE extract or ECGLE-based mouthwash formulation, the lower the viability of hDPPCs, but the greater the antibacterial activity.

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“…Karies gigi dapat dicegah dengan beberapa cara, salah satu diantaranya dengan pengguanaan mouthwash. Mouthwash adalah larutan yang mengandung zat penyegar nafas, adstringen, demulen, surfaktan dan atau antibakteri untuk menyegarkan dan membersihkan saluran udara di mana penggunaannya adalah dengan cara membilas 3 . Obat kumur dapat digunakan untuk banyak tujuan diantaranya untuk pencegahan dan terapeutik.…”

Section: Pendahuluanunclassified

FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN MOUTHWASH DARI EKSTRAK ETANOL DAUN SUKUN (Artocaprus altilis (Parkinson) Forsbeg)

Rantika

Sriarumtias

Fadilah

2019

JIFB

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Masalah kesehatan mulut yang sering terjadi salah satunya adalah karies gigi. Karies gigi dapat tejadi pada seseorang akibat adanya antara mineral gigi dengan biofilm oral. Karies gigi dapat dicegah dengan beberapa cara, salah satu diantaranya dengan pengguanaan mouthwash. Mouthwash merupakan larutan yang dapat menyegarkan dan membersihkan saluran udara di mana penggunaannya adalah dengan cara membilas. Telah dilakukan penelitian mengenai formulasi serta uji aktivitas antibakteri Streptococcus mutans dari sediaan mouthwash dari ekstrak etanol daun sukun ( Artocaprus altilis )Parkinson ) Forsbeg.). Tujuan pada penelitian ini adalah untuk mengetahui apakah formula sediaan mouthwash ekstrak etanol daun sukun dengan konsentrasi yang bervariasi, yaitu F1=5 %; F2=10 %; dan F3=15 % memiliki aktivitas antibakteri dan stabilitas secara fisik yang baik. Pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi agar. Evaluasi fisik sedian mouthwash meliputi pengamatan organoleptik, pengukuran pH, penentuan viskositas dan uji kesukaan. Hasil penelitian yang telah dilakukan menunjukkan bahwa formula yang stabil, memiliki aktivitas antibakteri dan disukai oleh panelis yaitu formula 1 dengan konsentrasi ekstrak etanol daun sukun sebesar 5%. Dengan zona hambat pada bakteri Streptococcus mutans sebesar 19,1 mm. Kata kunci: karies gigi, mouthwash, daun sukun, antibakteri

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Formulation and Evaluation of Antibacterial Herbal Mouthwash Against Oral Disorders

Cited by 18 publications

References 5 publications

Antimicrobial activities of mouthwashes obtained from various combinations of Elettaria cardamomum Maton., Lavandula angustifolia Mill. and Salvia triloba L. essential oils

Antimicrobial activities of mouthwashes obtained from various combinations of Elettaria cardamomum Maton., Lavandula angustifolia Mill. and Salvia triloba L. essential oils

In vitro cytotoxicity of ethanolic extract of the leaf of Calotropis gigantea from Ie Jue Geothermal Area, Aceh-Indonesia, and its mouthwash formulation against dental pulp cells

FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN MOUTHWASH DARI EKSTRAK ETANOL DAUN SUKUN (Artocaprus altilis (Parkinson) Forsbeg)

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