Formulation and Evaluation of Ascorbic acid Lozenges for the treatment of Oral Ulcer

Bhandarkar, Akansha; Alexander, Amit; Bhatt, Aditi; Sahu, Pankaj; Agrawal, Palak; Banjare, Tripti; Gupta, Swapnil; Sahu, Hemlata; Diwedi, Shradha Devi; Sahu, Siddharth Kumar; Yadav, Pooja; Sahu, Kailash C.; Dewangan, Deeksha; Thapa, Hemlata; Deepika,; Verma, Vinay Sagar; Sharma, Mukesh; Tripathi, D. K.; AJAZUDDIN, .

doi:10.5958/0974-360x.2018.00243.3

Cited by 8 publications

(6 citation statements)

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“…The preformulation study various polymer such as methylcellulose, locust bean gum, HPMC, K4M and xanthan gum was used for controlling dissolution rate of the lozenges. The Formulation was found to be having satisfactory stability-indicating the lozenges format could be an attractive dosage form for the administration of ascorbic acid through oral route [51]…”

Section: Ascorbic Acid Lozengesmentioning

confidence: 99%

The Research Updates and Prospects of Herbal Hard-Boiled Lozenges: A Classical Platform With Promising Drug Delivery Potential

Sahoo¹,

Male²,

Varier³

2021

Int J App Pharm

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Over the past decades major focus has been given towards innovative drug delivery systems and new dosage forms. This is due to highly expensive process and high attrition rates of existing marketed drugs. Hard-boiled lozenges (HBLs) are one of the solid dosage form designed to release the drug in saliva for either local or systemic effects. Typical application of lozenegs includes throat infection, pharyngitis, cough suppressant, nasal-decongestant, expectorants, and smoking cessation. The drug delivery through the hard-boiled candies has an easy marketing advantage due to its attractive appearance and patient compliance. As a part of the drug is absosrbed into systemic circulation, gastrointestinal degradation and fast pass effects are avoided. Further, drug delivery through hard-boiled lozenges can be potential platform for some of the suitable drug candidates. This review on hard-boiled lozenges discusses manufacturing process, characterization techniques, quality control, research studies and market potential of hard-boiled lozenges. The major databases searched were, PubMed, Wiley Online, Medline, Elsevier, Google scholar, Scopus, ACS, The Royal Society of Chemistry, SciFinder, Baidu Scholars, CNKI, web of science, Cochrane database, US Patents, Espacenet and various business reviews. This review provides comprehensive information on hard-boiled lozenges that will help the pharmaceutical scientist from academia as well pharmaceutical industry to leverage the potential of this conventional dosage form for various herbal drugs and other pharmaceutical actives.

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Section: Ascorbic Acid Lozengesmentioning

confidence: 99%

The Research Updates and Prospects of Herbal Hard-Boiled Lozenges: A Classical Platform With Promising Drug Delivery Potential

Sahoo¹,

Male²,

Varier³

2021

Int J App Pharm

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“…Jika hard candy klotrimazol menggunakan talk untuk menghindari lengketnya campuran, pada formulasi tablet hisap asam askorbat dengan penambahan xanthan gum sebesar 5% yang memiliki sifat thickening dapat menstabilkan formulasi. [22] Pada tablet biasa permukaan yang lengket juga bisa disebabkan oleh kadar air yang tinggi. [42] Pada pembuatan tablet hisap ini juga digunakan glukosa dan asam sitrat.…”

Section: Pembahasanunclassified

“…[42] Pada pembuatan tablet hisap ini juga digunakan glukosa dan asam sitrat. [22] Sedangkan, pada studi sebelumnya dijelaskan bahwa penambahan gula dengan berat molekul rendah (glukosa, fruktosa) dan asam organik (asam sitrat, malat, dan tartrat) merupakan tantangan tersendiri pada pembuatan serbuk menggunakan teknologi spray drying.…”

Section: Pembahasanunclassified

“…[44] Oleh kerana itu xanthan gum merupakan pilihan yang tepat untuk dijadikan sebagai agen penstabil dalam formulasi tablet hisap yang mengandung asam askorbat. [22] Pada formulasi soft lozenge klotrimazol, kekerasan tablet hisap meningkat karena jumlah PEG 1500, xanthan gum atau xylitol meningkat. Peningkatan waktu disintegrasi dapat juga disebabkan oleh peningkatan jumlah talk dalam formula menjadi sebesar 15% namun kekerasan tablet tidak terpengaruh oleh penambahan talk.…”

Section: Pembahasanunclassified

“…[23] Xanthan gum dapat mendukung pelepasan obat selama 30 menit, hal ini mungkin disebabkan oleh peningkatan viskositas permen oleh xanthan gum. [22] Pada formulasi tablet hisap nikotin biasanya dibuat dalam bentuk troches (compressed tablet lozenges, menggunakan basis bebas gula karena ditujukan untuk pasien diabetes yang merokok. Namun rasa burning after tastes dan bau menyengat dari nikotin tidak dapat tertutupi hanya dengan penggunaan basis bebas gula saja, sehingga ditambahkan kyron T114 sebagai taste masking agent.…”

Section: Pembahasanunclassified

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Formulasi dan Evaluasi Tablet Hisap Mengandung Zat Aktif Bersifat Higroskopis

2020

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Tablet hisap banyak dikembangkan dalam industri farmasi karena kelebihannya yang lebih mudah diterima oleh pasien terutama pada anak-anak, rasa yang enak, bentuknya yang menarik seperti permen serta praktis dalam penggunaannya. Namun tidak semua zat aktif dapat dijadikan ke dalam bentuk sediaan ini sehingga studi-studi mengenai formulasi tablet hisap yang mengandung senyawa obat masih terbatas terutama zat aktif yang bersifat higroskopis. Kelembapan dapat mempengaruhi sifat fisika, kimia, dan mikrobiologi dari sediaan solid. Oleh karena itu dalam review artikel ini akan dibahas mengenai zat aktif higroskopis apa saja yang diformulasikan, standar pengujian evaluasi dalam menentukan kualitas sediaan tablet hisap, eksipien, polimer, serta metode pembuatan yang digunakan. Metode yang digunakan dalam artikel review ini yaitu studi pustaka dengan melakukan akses digital terhadap situs pencarian jurnal. Hasil menunjukkan zat aktif yang bersifat higroskopis dapat diformulasikan menjadi berbagai tipe tablet hisap yang memenuhi parameter yang telah ditetapkan dengan pemilihan metode, eksipien serta polimer yang tepat. Eksipien yang dapat digunakan antara lain adalah HPC, xanthan gum, talk, HPMC E-15, akasia, metil selulosa, kyron T114 dan PEG 6000.

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Recent Developments in Medicated Lozenges: A Promising Dosage Form for the Effective Delivery of Therapeutic Agents

Sharma

Dinesh

Gurmeet

2021

DDL

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Background: The delivery of therapeutic agents through the oral route remains the most favorable one as compared to other routes of drug administration. However, numerous disadvantages are encountered in conventional formulations such as low bioavailability, first-pass metabolism, gastric irritation, delayed onset of action, bitter taste, low retention time, frequent dosing, and non-localized drug targeting. All these problems encountered guide the various pharmaceutical industries to manufacture and develop a novel solid oral dosage form called lozenges. Lozenges are solid oral dosage forms of medicament, meant to be dissolved within the mouth or pharynx. It may consist of one or more than one medicinal agent contained in a sweetened and flavored base material. Objective: The present review is focused on various types, compositions, methodologies used to prepare the medicated lozenges and on different evaluation parameters that establish its safety and efficacy. It also put a light on different commercially available and reported medicated lozenges formulation. Method: The various review and research articles reported by different researchers were studied extensively by using the databases of Google Scholar, Pubmed, Scopus, Web of Science and various commercial websites that were also investigated for information regarding new products. Results: Lozenges provides various advantages in terms of patient compliance, rapid onset of action, prolonged retention time, enhancement of bioavailability, ease of manufacturing, localized drug targeting, sustained or controlled effect, and reduced dosing frequency. It has also the ability to incorporate the drugs belong to different therapeutic classes for treating various disorders related to oral cavities like gingivitis, dental plaque, mouth ulcers, throat pain, oral thrush, throat infection, periodontitis, and pharyngitis. However, its applicability is not only limited to localized action, but it has also been employed to deliver the drug systemically for the conditions such as cough, decongestion, runny nose, nausea, vomiting, allergy, low immunity, fever, body ache, the killing of worms and smoking cessation. Conclusion: It was concluded that it has been played an important role in the field of drug delivery and will continue to perform in the same way in the future as well.

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Formulation and Evaluation of Ascorbic acid Lozenges for the treatment of Oral Ulcer

Cited by 8 publications

References 0 publications

The Research Updates and Prospects of Herbal Hard-Boiled Lozenges: A Classical Platform With Promising Drug Delivery Potential

The Research Updates and Prospects of Herbal Hard-Boiled Lozenges: A Classical Platform With Promising Drug Delivery Potential

Formulasi dan Evaluasi Tablet Hisap Mengandung Zat Aktif Bersifat Higroskopis

Recent Developments in Medicated Lozenges: A Promising Dosage Form for the Effective Delivery of Therapeutic Agents

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