Formulation and Evaluation of Aspirin-Loaded Plga Nanoparticles for Ophthalmic Use

Abstract

Objective: The objective of this work was to increase the bioavailability of Aspirin to the retina by increasing its bioavailability to blood. This was achieved by forming aspirin-loaded PLGA nanoparticles Methods: Aspirin-loaded PLGA nanoparticles were prepared by a solvent evaporation process. The PLGA was dissolved in the proper solvent and added dropwise to the Aspirin-albumin solution revolving at 3000 rpm. Glutaraldehyde was used as a cross-linker at 20% concentration. The nanoparticles were obtained after passing the solution through HPH and subsequent centrifugation. Results: The prepared nanoparticles were found to be spherical with the smooth surface as seen in SEM. and with a size of 160.9 nm. Aspirin-loaded PLGA nanoparticles showed in vitro drug release of 71.4 % and ex-vivo permeation of 66.2 %. The formulation was found to be stable for six months. Conclusion: The developed aspirin-loaded polymeric nanoparticles could be effective for the controlled delivery of aspirin in the early prevention of diabetic retinopathy.

Fabrication, Characterization, and in vitro Evaluation of Atenolol Loaded Microsponges for Ocular Delivery

“…The basic reason behind high DC was the spongy nature of formulation which can accommodate high drug load. The results were in co-relation with the work done byPethe et al;…”

“…The maximum percentage yield was found for formulation FE9 having high amount of polymers while the low percentage yield was observed for FE1 formulation which contains low amount of polymers. The study suggests that as the concentration of polymer was raised, 19 The results of EE vary from 58.23% to 81.87%. Among all the formulations, the maximum entrapment efficiency was found for FE8 (82.81%) while minimum entrapment efficiency was FE1 (58.23%) formulation.…”