Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide

Kadam, Sagar; Yadav, Pradip; Landge, Dhananjay

doi:10.5958/0974-360x.2020.00264.4

Cited by 5 publications

(2 citation statements)

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“…The kinetic models of drug release will determine using Zero-order, irst-order, Hixson-Crowell, higuchi and Korsmeyer-Peppas models (Baishya et al, 2017;Kadam et al, 2019).…”

Section: Kinetic Model Drug Releasementioning

confidence: 99%

Controlled drug release of levofloxacin from poly (acrylamide) hydrogel

Madhusudana

Mamatha

Demappa

et al. 2021

ijrps

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Hydrogels are 3D polymer networks capable to absorb and release water or biological fluids. They are stimuli-responsive materials, which can show rapid volume changes with response to small changes in environmental parameters such as ionic strength, pH, and temperature. In this work, we performed a synthesis of Poly(acrylamide) hydrogel and tested for controlled release of levofloxacin hemihydrate as a model drug. We used sodium metabisulfite and potassium persulphate as free radical initiators to prepare hydrogel with methylenebisacrylamide as a crosslinker. Characterization of hydrogel was performed by TGA, SEM, and FT-IR. Swelling study and drug release were performed at pH 1.2 and 7.4 solutions, identical to the gastrointestinal fluid at 37°C (human body temperature) to examine possible site-specific drug delivery. UV-Visible spectrophotometer was used to measure the concentration of drug release. Results exhibited the pH and temperature-dependent drug release. The amount of drug release was found to be 17% and 99% in acidic and alkaline pH of 1.2 and 7.4, respectively, after 6 hours.

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“…The kinetic models of drug release will determine using Zero-order, irst-order, Hixson-Crowell, higuchi and Korsmeyer-Peppas models (Baishya et al, 2017;Kadam et al, 2019).…”

Section: Kinetic Model Drug Releasementioning

confidence: 99%

Controlled drug release of levofloxacin from poly (acrylamide) hydrogel

Madhusudana

Mamatha

Demappa

et al. 2021

ijrps

View full text Add to dashboard Cite

show abstract

“…Moreover, they can be designed to be sensitive to a specific internal factor (pH, redox, or temperature) or external factor (laser irradiation, magnetic field, or ultrasound), which can provide an on-demand drug release strategy [ 50 , 51 , 52 , 53 ]. In conventional pharmaceutical finished products, an enteric coating can be used for controlling the drug release process after oral administration [ 54 , 55 , 56 ]. Other strategies including surface-modification of the microscale and nanoscale drug carriers [ 57 , 58 ], using specific organic structures (as linkers) [ 59 , 60 ], can provide irradiation-triggered drug release [ 61 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy

Zhang¹,

Ganjali

Afruzi

et al. 2022

Heliyon

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Formulation design and Evaluation of Extended-Release Tablets of Oxybutynin for Effective Management of Overactive Bladder Syndrome

Nandhakumar

Sugreevudu

Harikrishnan

2021

RJPT

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Overactive bladder syndrome (OAB) is a chronic condition with a composite of symptoms and has a significant negative impact on the physiological and psychological well-being of the patients. The present study is aimed at developing extended-release formulations of oxybutynin that is effective in reducing the side effects associated with the drug by maintaining a steady state concentration with minimal fluctuations in plasma drug concentration and thereby achieves improved patient compliance. The extended-release drug delivery of tablets can be achieved by preparing the matrix tablet of oxybutynin chloride with klucel HF in core tablet by wet granulation technique and functional coating with a combination of aquacoat ECD-30 and hypromellose E5 followed by film coating with opadry. For confirmation of compatibility, the pure drug and its physical mixtures were subjected to FTIR studies. All the formulations have shown acceptable limits in all precompression and post compression parameters. The in vitro release studies in 0.1N HCl and 6.8 phosphate buffer revealed that the optimized formulation F10 extend the release of the drug to 91% at 24 hours and the release profile was similar to the innovator’s product as revealed by the similarity factor study. The release kinetics study revealed that the release of the drug followed diffusion mechanism. Stability studies of the selected formulation tablets were carried out at 25°C ±2°C/60% RH±5% and 40°C ±2°C /75%±5% RH for different time period and all the parameter was within the limits after storage period. Thus the extended release matrix tablets of oxybutynin chloride developed in this study have immense potential to develop into a marketed product following the testing in animals and human volunteers.

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Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide

Cited by 5 publications

References 0 publications

Controlled drug release of levofloxacin from poly (acrylamide) hydrogel

Controlled drug release of levofloxacin from poly (acrylamide) hydrogel

Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy

Formulation design and Evaluation of Extended-Release Tablets of Oxybutynin for Effective Management of Overactive Bladder Syndrome

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