Formulation and Evaluation of Colon Specific Drug Delivery of Press Coated Esomeprazole Tablets

Abstract

The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole. Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation characteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used in the formulation .Invitro release profiles of optimized form of F6 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. . In vitro release profiles of optimized formulation of Esomeprazole controlled release tablets (F-6) were found to be improvised and followed zero -order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

“…A method of production of tablets containing esomeprazole [ 267 ] for colon delivery was also developed. In the first stage, the tablet core containing the therapeutic substance was produced by direct compression.…”

“…In the final stage, the bilayer tablet was coated with a solution of hydroxypropylmethylcellulose phthalate (HP-55). Tablets were characterized by acid resistance with further release of therapeutic substances for up to 8 h [ 267 ].…”

An Overview: Development of Colon Drug Delivery System and Its Application and Limitations

“…One of the concerns is the drug delivery system to the large intestine (colon). The colon is referred to as the optimal place of the absorption of proteins and polypeptides after oral administration due to the relatively low activity of proteolytic enzymes and a sufficiently long transit time in the colon [2]. A large number of polysaccharides such as pectin, amylose, guar gum, chitosan, inulin, cyclodextrin, chondroitin sulfate, detraction, and dextrin have been identified for their use for targeted drug delivery system in the colon [3].…”

Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery

“…These systems have been developed for local treatment of different inflammatory bowel diseases, such as Crohn’s disease, ulcerative colitis, colon cancer, local treatment of colonic diseases and systemic delivery of protein and peptides [ 32 ]. There are several strategies for achieving colon-specific targeting including 3D-printed systems [ 33 ], enzyme-responsive systems [ 34 , 35 ], microparticulate [ 36 , 37 , 38 ] and nanoparticulate systems [ 39 , 40 ], film- and press-coated formulations [ 41 , 42 , 43 , 44 ]. Eudragit ® copolymers also can be used in colon-specific drug delivery systems.…”