Formulation and evaluation of controlled release Eudragit buccal patches

Wong, Choy Fun; Yuen, Kah Hay; Peh, Kok Khiang

doi:10.1016/s0378-5173(98)00342-1

Cited by 132 publications

(54 citation statements)

References 23 publications

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“…The peak detachment force was used to evaluate the bioadhesive force of the films. 17 PCL film was used as a negative control, while pure CH film was used as a positive control. Each measurement was repeated at least 4 times.…”

Section: In Vitro Bioadhesionmentioning

confidence: 99%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

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The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. Mucoadhesive micromatricial chitosan/poly(ε-caprolactone) (CH/PCL) films and chitosan films were prepared. Thermal behavior, morphology, and particle size measurements were used to evaluate the prepared films. The effect of different molar masses of CH and different ratios of medium Mwt molar mass chitosan (MCH):PCL on water absorption, in vitro bioadhesion, mechanical properties, and in vitro drug release was examined. In vivo performance of the selected formulation was also evaluated. Differential scanning calorimetry examination revealed that MET existed mainly in amorphous form. Under microscopic examination, PCL microparticles were homogeneously dispersed in the films. The use of different molar masses of CH and different ratios of (MCH):PCL affected the size of the entrapped particles. Addition of PCL significantly decreased percentage water uptake and bioadhesion force compared with pure CH film. With regard to mechanical properties, the 2-layered film containing 1:0.625 MCH:PCL had the best tensile properties. At fixed CH:PCL ratio (1:1.25), the slowest drug release was obtained from films containing high molar mass CH. On the other hand, the 2-layered film that consisted of 1:0.625 MCH:PCL had the slowest MET release. In vivo evaluation of the selected film revealed that metronidazole concentration in saliva over 6 hours ranged from 5 to 15 μg/mL, which was within and higher than the reported range of minimum inhibitory concentration for metronidazole. A significant in vitro/in vivo correlation under the adopted experimental conditions was obtained.

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Section: In Vitro Bioadhesionmentioning

confidence: 99%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

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“…The bioadhesive strength of the films was evaluated by the modified method of Wong et al 13 The measurement was conducted with a texture analyzer equipped with a 5-kg load cell and bioadhesion test rig. Chicken back skin was used as a model tissue.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

et al. 2007

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The aim of this study was to develop chitosan film containing fucoidan and to investigate its suitability for the treatment of dermal burns on rabbits. Porous films, thickness between 29.7 and 269.0 μm, were obtained by the solvent dropping method. Water vapor permeability (3.3-16.6/0.1 g), the swelling (0.67-1.77 g/g), tensile strength (7.1-45.8 N), and bioadhesion (0.076-1.771 mJ/cm 2 ) of the films were determined. The thinnest films were obtained with the lowest chitosan concentration (P G .05). The water absorption capacity of the films sharply increased with the freeze-drying technique. The film having the thickness of 29.7 μm showed the highest amount of moisture permeability (16.6 g/0.1 g). Higher chitosan concentration significantly increased tensile strength of the films (P G .05). Using higher concentration of lactic acid made films more elastic and applicable, and these films were selected for in vivo studies. Seven adult male New Zealand white rabbits were used for the evaluation of the films on superficial dermal burns. Biopsy samples were taken at 7, 14, and 21 days after wounding, and each wound site was examined macroscopically and histopathologically. After 7 days treatment, fibroplasia and scar were observed on wounds treated with fucoidan-chitosan film. The best regenerated dermal papillary formation, best reepithelization, and the fastest closure of wounds were found in the fucoidan-chitosan film treatment group after 14 days compared with other treatment and control groups. It can be concluded that fucoidan-chitosan films might be a potential treatment system for dermal burns and that changing formulation variables can modulate the characterizations of the films.

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“…It was fixed on one slide, moistened with 1 ml simulated saliva solution while the film was fixed to another slide. Then the fixed film was placed on the chicken pouch [21,22] and left for 10 seconds applying a force of 10 g so that the adhesion bonding forces could be established. The apparatus was allowed to move down at a constant rate of 2 mm/min till the two sides were separated.…”

Section: Determination Of Mucoadhesionmentioning

confidence: 99%

Chitosan Mucoadhesive Buccal Films: Effect of Different Casting Solvents on Their Physicochemical Properties

Abouhussein

El-Bary

Shalaby

et al. 2016

Int J Pharm Pharm Sci

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Objective: The aim of this work is to investigate the influence of different casting solvents on the physicochemical properties of cetylpyridinium chloride (CPC) chitosan mucoadhesive buccal films.Methods: Screening formulations were prepared by casting solvent technique using organic acids; 1% acetic acid (AA), 1% lactic acid (LA) and inorganic acid; 0.1N HCl (FS1-FS3). Then, 2P 1 P X3P 1 P factorial design study was done using 2 factors; solvent type (AA, LA, Mixture of 0.1N HCl and LA) and solvent concentration (AA and LA; 1%, 2% and mixture of 0.1N HCl: 1% LA; 2:1, 1:2). Films were evaluated for their physicochemical properties through, mechanical properties, mucoadhesion, in vitro release of CPC and antimicrobial activity. Results:The studied factors showed a significant effect on both mucoadhesion and tensile strength. Film casted from 0.1 N HCl was brittle and did not show any elasticity, so it was used in further studies mixed with LA to improve physicochemical properties of the prepared films. Films casted from LA showed swelling for an initial period of 15 min then no more swelling occurred while swelling of those casted from AA occurred throughout approximately 2 h. A film containing 2:1 HCl: LA (F5) dissolved in both media while 1:2 HCl: LA (F6) showed swelling properties. This was reflected on the in vitro release of CPC in which F5 gave higher % released (DER 300 min R54.37%) than the other formulations. Conclusion:Casting solvent was proved to have a significant effect on the physicochemical properties of chitosan CPC mucoadhesive films.

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Formulation and evaluation of controlled release Eudragit buccal patches

Cited by 132 publications

References 23 publications

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

Chitosan Mucoadhesive Buccal Films: Effect of Different Casting Solvents on Their Physicochemical Properties

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