Formulation and Evaluation of Dispersible Tablets of Flavonoid Pgal Isolated From Saraca Asoca Leaves

Abstract

Objective: The study aimed to design and evaluate a dispersible tablet of flavonoid PGAL isolated from Saraca asoca leaves for antidepressant activity. Methods: The phytoconstituent was isolated from a methanolic extract of Saraca asoca leaves using silica gel column (60-120 mesh) chromatography. The dispersible tablets were prepared by direct compression and then evaluated for various tablet evaluation parameters and antidepressant activity, performing Tail Suspension Test (TST), Forced Swim Test (FST), Locomotion activity, Brain glutamate level and brain nitrite level. Results: Hardness of 2.85±0.13 kg/cm2 to 3.25±0.15 kg/cm2 and friability of 0.35% to 0.48% indicate that the prepared tablets were mechanically sound. Test for weight variation was also within tolerance limits, i.e. 2.04% to 4.25% difference in weight of the tablet from the average weight of 10 tablets. The tablets also passed the test for drug content uniformity, 97.35% to 100.35%, i.e. always within the prescribed limits of 95% to 105%. Disintegration time, 2 min to 2.75 min, and dispersion time, 3.25 min to 3.75 min, were also exemplary. The antidepressant activity was displayed by the optimized formulation as indicated by a significant decrease (p<0.05) in immobility time in TST as well as FST; a significant decrease (p<0.05) in the level of brain tissue glutamate as well as nitrite in PGAL formulation treated mice when compared with negative control, as did by standard drug fluoxetine. Conclusion: The formulation has been optimized based on dispersion time. The formulation with minimum dispersion time, i.e. F1, has been considered an optimized formulation. The prepared optimized formulation was found to comply with all physical parameters and antidepressant activity.

Lozenges Formulation of Ciplukan (Physalis Angulata L.) Fruit Extract as an Antioxidant With Combination of Filler Agents Avicel Ph 102–ludipress

“…Then the results are recorded and the average is calculated, followed by calculating the standard deviation of each tablet from the average weight. Not more than two individual weights differ from the average weight by more than 5% and neither by more than 10% [13].…”

“…It is defined as the maximum possible angle between the surface of the powder pile and the horizontal plane [12]. To determine the Angle of Rest, the powder is passed through a funnel that is aligned vertically, and the height (h) and radius (r) of the pile formed is determined and the angle of rest is calculated using the following formula [13].…”

“…Tapped density is obtained using granules as much as 20 g mechanically tapped graduated measuring cylinder using a bulk density apparatus until a constant volume is followed by calculation using the following formula [13].…”

“…A Monsanto Hardness Tester measured the hardness of the prepared tablets. The tablet was placed between two anvils; the force applied to the anvils and the crushing strength that caused the tablet to break was recorded [13].…”

Development of a Reference Sample for Rapid Analysis of an Elemental Composition of Medicinal Plant Raw Materials

“…The use of medicinal plants in the treatment of many diseases is progressing everywhere due to the breadth of the therapeutic range and the low incidence of side effects. Also, medicinal plants are used for the manufacture of various delivery systems for medicinal substances, for example, nanoparticles based on various forms of metal [1][2][3].…”