2018
DOI: 10.12928/pharmaciana.v8i2.9203
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Formulation and evaluation of erythropoietin-alginate microspheres at different amount of drug

Abstract: This research formulate erythropoietin-alginate microspheres and to evaluate characteristics of erythropoietin-alginate microspheres at different amount of drug using aerosolization. Amount of erythropoietinare 10,000 IU (F1); 20,000 IU (F2); 60,000 IU (F3). The mixture of erythropoietinalginate was sprayed into CaCl 2 and was stirred at 1000 rpm for 30 minutes. Formulas resulted spherical shape of microspheres. The size of microspheres was 2.77 µm for F1; 3.89µm for F2; and 4.42µm for F3. The results of swell… Show more

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