Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion

Eisa, Aya M.; El-Megrab, Nagia A.; El-Nahas, Hanan M.

doi:10.1016/j.jsps.2022.09.002

Cited by 15 publications

(3 citation statements)

References 19 publications

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“…Previously, the method was repeated numerous times for nine refluxes totalling around three hours, followed by one extraction. Previously, a thermometer was used to control the temperature [11].…”

Section: Preparation Of Extractmentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

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Objective: The present work is aim to design, development and fabrication of mouth dissolving tablets containing extract of Tribulus terrestris for the treatment of hypertension. Methods: The extract of fruits of Tribulus terrestris was formulated as mouth dissolving tablets (MDTs) by full factorial design at 32 levels and prepared by direct compression method using super integrants like sodium starch glycolate and cross povidone. Furthermore, the tablet was evaluated for thickness, hardness, weight variation, wetting time, disintegration time, and in vitro drug release study. Results: The tablets were analyzed for a variety of characteristics, such as hardness (2.4-2.9 kg/cm2), friability (0.33-1.7%), disintegration time (20-34 s), drug content (95.32-99.09%), water uptake ratio (26-48%), wetting time (29-69 s), and in vitro drug release illustrated in 5 min (99.04-68.21%). There was no interaction between both the drug and the polymer, according to FTIR and DSC studies. Conclusion: The research revealed that Tribulus terrestris fruits extract can be designed, developed and fabricated into mouth dissolving tablet for the treatment of hypertension with improved bioavailability and expected patient compliance.

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Section: Preparation Of Extractmentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

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“…The rapid disintegration of the MDT tablets may be explained by the water's speedier entry into the tablet's pores, which may have caused super disintegrants to expand and provide sufficient hydrodynamic pressure for rapid and total disintegration. Wetting time was employed as a measure to correlate with oral cavity disintegration time since it is directly related to the inner structure of the tablets and the hydrophilicity of the excipients [30]. Wetting time may be the cause of disintegration because the breakdown process of a tablet depends on wetting time, followed by disintegration.…”

Section: In Vitro Dissolution Study Of Mdtmentioning

confidence: 99%

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

et al. 2023

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Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a concentration of Crospovidone 30 mg, shows 91.30% drug release respectively at the end of 12 min. Conclusion: The mouth-dissolving tablets of ambrisentan were successfully designed, developed, and fabricated. It can be reasonably concluded that the AS6 batch of mouth-dissolving tablets of ambrisentan with 30 mg of crospovidone exhibited maximum cumulative drug release in 12 min.

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“…Because of the high stability, smaller bulk, accurate dose, easy manufacturing, and repeatable in vivo plasma concentration following oral administration, the majority of novel chemical entities are designed to be operated as the solid dosage form. 1 Solid oral dosage forms have major influence over other types of oral dosage forms. 2,3 There are more promising medicine candidates available due to technological advancement, however, the majority of active pharmaceutical ingredients (APIs) with high possibility, low and alterable oral bioavailability due to their poor aqueous solubility at physiological pH and resulting decrease in dissolution rate, which causes a number of challenges when creating oral solid dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and Evaluation of Solid Dispersion of Deferasirox Using Factorial Design

Talla,

Wadher,

Umekar

et al. 2024

J. Drug Delivery Ther.

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Deferasirox, an oral iron-chelating agent, is a poorly soluble drug (Biopharmaceutical Classification System class II) having insufficient solubility in physiological fluids resulting in low bioavailability of the drug. The idea behind the present study was to explore the prospects of solid dispersion as a prolific method to enhance the dissolution rate of drug using a water soluble polymer. The solid dispersion was prepared by the solvent evaporation technique using Polyvinyl pyrrolidone with different drug to carrier and solvent ratio. Formulations were characterized through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), Powder X-ray diffraction (XRD), and in vitro release studies. A 32 factorial design was implemented to obtain optimum solubility, % yield, and optimization of solid dispersion (SD) also quantitates the influence of PVP on the solubility and dissolution profile. Thedrug-to-carrier and solvent ratio was chosen as independent variable, while %yield, drug content, and saturation solubility were chosen as dependent variables. The results showed that the optimized formulation of SD-DFX was able to significantly enhance its solubility. The SD containing a dispersion of Deferasirox with PVP show an exceptional rise in the solubility. This study describes the development of solid dispersion that significantly improved the solubility and bioavailability of DFX. The FTIR studies indicate the interaction between the drug and polymer. The DSC and XRD analysis indicated that the drug was in an amorphous state when dispersed in the polymer. It is resolved that the SD method significantly improves the solubility and dissolution rate, which could also be exploit for other poorly water soluble drug candidates. Keywords: Deferasirox , Polyvinyl pyrrolidone, solid dispersion, Factorial design, Solubility

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Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion

Cited by 15 publications

References 19 publications

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

Formulation, Optimization and Evaluation of Solid Dispersion of Deferasirox Using Factorial Design

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