Formulation and Evaluation of Fast-disintegrating Tablets of Flurbiprofen and Metoclopramide

Mushtaq, Maria; Fazal, Nosheen; Niaz, Amna

doi:10.1007/s12247-020-09455-z

Cited by 6 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peaks at 1635cm -1 and 1594cm -1 were attributed to S=O stretching of sulfate and N-H stretching of nitro compounds, respectively. Other characteristic peaks were observed at 835 cm -1 and 678 cm -1 that were due to C-Cl stretching of alkyl halide group and C-Br stretching of halo compounds (Figure 2A) (Mushtaq, Fazal, Niaz, 2020). Eudragit L100 revealed characteristic peaks at 3417 cm -1 , 2830 cm -1 and 2194 cm -1 that attributed to C=O stretching, C-H stretching and carbonyl vibrations of ester group (Figure 2B).…”

Section: Ftir Analysismentioning

confidence: 98%

Development and optimization of metoclopramide containing polymeric patches: impact of permeation enhancers

Sarwar

Farooq

Adnan

et al. 2022

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The study is aimed to develop a monolithic controlled matrix transdermal patches containing Metoclopramide as a model drug by solvent casting method. Eudragit L100, Polyvinylpyrrolidone K-30, and Methylcellulose were used in different ratios and Polyethylene glycol 400 added as a plasticizer. Resulting patches were evaluated for their physicochemical characters like organoleptic characters, weight variation, folding endurance, thickness, swelling index, flatness, drug content, swelling index, percentage erosion, moisture content, water vapor transmission rate and moisture uptake. Formed patches were also evaluated through Fourier transform spectroscopy (FT-IR), X-ray diffraction (XRD), Differential Scanning calorimetry (DSC) and Scanning Electron Microscopy (SEM). Results of SEM unveiled smooth surface of drug-loaded patches. In-vitro dissolution studies were conducted by using dissolution medium phosphate buffer saline pH 7.4. Effect of natural permeation enhancers was elucidated on two optimized formulations (Z4 and Z9). Different concentrations (5%-10 %) of permeation enhancers i.e. Olive oil, Castor oil and Eucalyptus oil were evaluated on Franz diffusion cell using excised abdominal rat skin. Z4-O2 (Olive oil 10%) had enhanced sustain effect and flux value (310.72) close to the desired flux value. Z4-O2 followed Higuchi release model (R 2 = 0.9833) with non-fickian diffusion release mechanism (n=0.612).

show abstract

Section: Ftir Analysismentioning

confidence: 98%

Development and optimization of metoclopramide containing polymeric patches: impact of permeation enhancers

Sarwar

Farooq

Adnan

et al. 2022

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…The weight variation was checked for individual tablets and deviation can be calculated by the given formula. 25 % Weight variation = (weight of single tablet-Average weight of 20 tablets) × 100%…”

Section: Weight Variation (W) Testmentioning

confidence: 99%

Preparation and Evaluation of Polymer Fused Metformin Hydrochloride Sustained Release Tablet

Butola¹,

Bhatt²,

Nainwal³

et al. 2023

Ind. J. Pharm. Edu. Res.

View full text Add to dashboard Cite

Introduction: Diabetes Mellitus (DM) is one of the most prevalent and chronic illnesses associated with an abnormally high level of glucose in the body which is hazardous to the body organs. Metformin Hydrochloride (HCl), a biguanide derivative is used for Type 2 DM. It has a relatively short plasma half-life and its regular administration is required to maintain a normal blood glucose level in diabetic patients. Therefore, sustained-release medications are a suitable approach to increase patient compliance and extend the duration of the effect of metformin for 8-12 hr. The main goal of this investigation was to prepare an oral sustained-release tablet of metformin HCl using natural polymers as release rate-controlling agents. Materials and Methods: Polymer fused metformin hydrochloride sustained-release tablet was formulated with sodium alginate, and pectin alone and in combinations at different ratios, by direct compression method. Evaluations: The formulation was evaluated for pre-compression parameters, like drug-excipient interaction (using Fourier-transform infrared spectroscopy), drug solubility, flow properties and density of powder blends. The compressed tablets were evaluated for diameter, friability, thickness, weight variation, hardness, content uniformity and in vitro drug release. Results: The drug release study showed that sodium alginate and pectin alone and in combination were able to sustain the drug release. It is also suggested that if the amount of polymer increased, the drug release decreased. Formulation (MA3) containing the highest amount of sodium alginate (250mg) gave 93.06% drug release after 12 hr and was therefore chosen as the best formulation. Diffusion and erosion may be the mechanism of drug release, according to the kinetic modelling of the in vitro drug release.

show abstract

“…Results demonstrated the superior performance of cross-linked superdisintegrants as disintegration times of CP (26 sec) and SSG (49 sec) were significantly shorter than the one recorded with potato starch (149 sec) [5]. Tablet formulations of irbesartan [6], amoxicillin [7], spironolactone [8], flurbiprofen and metoclopramide [9] containing novel cross-linked superdisintegrants disintegrated rapidly.…”

Section: Super-disintegrantsmentioning

confidence: 99%

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Arshad

Zafar

Yousef

et al. 2021

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Formulation and Evaluation of Fast-disintegrating Tablets of Flurbiprofen and Metoclopramide

Cited by 6 publications

References 18 publications

Development and optimization of metoclopramide containing polymeric patches: impact of permeation enhancers

Development and optimization of metoclopramide containing polymeric patches: impact of permeation enhancers

Preparation and Evaluation of Polymer Fused Metformin Hydrochloride Sustained Release Tablet

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Contact Info

Product

Resources

About