Formulation and Evaluation of Floating Drug Delivery System for Oxcarbazepine

Manoharan, Gunasekar; Nagarajan, B.; Gottam, Bhargava

doi:10.31080/asps.2022.06.0845

Cited by 2 publications

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“…X 1 and X 2 stand for the main effect, X 1 X 2 are the interaction terms and shows how the response changes when two factors are simultaneously changed. X 1 2 and X 2 2 are quadratic terms of independent variables to evaluate nonlinearity.…”

Section: Methodmentioning

confidence: 99%

“…Thus, there are numerous advantages such as improved efficacy, reduced toxicity, improved patient compliance and convenience etc. 1,2 . Thus considerations have led to the development of oral controlled release CR dosage forms possessing gastric retention capabilities are the control of the location of a drug delivery system, especially for drugs exhibiting an absorption window in the GI tract or drugs with a stability problem, in a specific region of the GI tract offers several advantages 3 .…”

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2022

IJPSR

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The objective of the present investigation was to develop an alginate-HPMC K4M microbead-based gastro-retentive drug delivery system incorporating Famotidine for the treatment of gastrointestinal ulcers. The 3 2 full factorial designs were used for the optimization of famotidine-loaded floating microbeads. Two factors were evaluated, each at 3 levels; experimental trials were performed for all nine possible combinations. The amount of HPMC K4M (X1) and rotations of stirring speed (X2) were selected as independent variables. The % entrapment efficiency, % drug release at 12 hr, and % buoyancy were selected as dependent variables. The morphological properties, mean particle size, drug entrapment efficiency, drug loading, in-vitro buoyancy studies, in-vitro drug release, and in-vivo antiulcer activity of microbeads were all investigated. The effect of formulation variables on the response variables was statically evaluated by applying ANOVA at a 0.05 level using the software Design Expert® 13 (Stat-Ease, USA). The average size of optimized alginate-HPMC K4M microbeads was 0.86±0.35mm, with estimated entrapment effectiveness of 71.43± 0.21%, cumulative drug release of 98.75± 0.50% and percent buoyancy of 88.82±0.26%. Alginate -HPMCK4M microbeads containing Famotidine were successfully prepared using full 3 2 factorial designs and can be utilized to treat peptic ulcers efficiently. In-vivo, antiulcer activity indicated that the improved microbeads formulation might prevent ulcer formation in rats' stomachs. The method presented appears to be promising for drug delivery to the stomach.

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Section: Methodmentioning

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confidence: 99%

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2022

IJPSR

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“…Gastroretentive drug delivery system provides several benefits for drugs exhibiting poor bioavailability due to the narrow absorption window in the upper part of the gastrointestinal tract. As it retains the drug at the site of absorption and thus enhances the bioavailability and reducing the wastage of drug [1][2][3]. Theophylline, a methylxanthine drug used in the treatment of asthma, has narrow therapeutic index of 5-20 µg/ml serum concentrations.…”

Section: Introductionmentioning

confidence: 99%

Formulation and <i>In Vitro </i>Evaluation of Gastroretentive Theophylline Floating Tablets

Venkatesh

Raman

Huy

2020

MSF

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The main aim of the present investigation was to formulate and evaluate gastroretentive floating tablets of theophylline. Theophylline, a brochodialator, used in the treatment of asthma, has good absorption at the gastric pH. Therefore, a floating drug delivery system in a gastric pH could deliver the drug in a slow and sustained manner which could be a useful for broncho dilation in the treatment of asthma. The formulated gastroretentive tablets of theophylline were evaluated for various parameters such as weight variation, hardnesss, friability, drug content, swelling index, buoyancy time and drug release studies. Among the different formulations, formulation F7 prepared using HPMC:Carbopol (1:1 ratio) exhibited better release profile (93.36%) for 8 hours and this batch was selected as an ideal batch. The release of theophylline from the ideal batch was found to follow diffusion mechanism.

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Formulation and Evaluation of Floating Drug Delivery System for Oxcarbazepine

Cited by 2 publications

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Formulation and <i>In Vitro </i>Evaluation of Gastroretentive Theophylline Floating Tablets

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