Formulation and evaluation of floating dosage forms: An overview

Sabale,; Sn, Sakarkar; Pund, Swati; Sabale, PM

doi:10.4103/0975-8453.59510

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…The gastric emptying occurs both during fasting state and fed state, but the pattern of motility differs in both of these states. [16,19] The GI motility of the stomach consists of two modes; they are inter-digestive motility pattern and digestive motility pattern. In the fasted state, the inter-digestive motility pattern is dominated.…”

Section: Physiology Of Stomachmentioning

confidence: 99%

Untitled

2020

IJPBA

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Floating drug delivery approach uses low-density systems that have sufficient buoyancy to flow over the gastric contents and remains buoyant in the stomach without affecting the stomachic emptying rate for a chronic period of time. This result is increased gastric retention time and better control of the fluctuations in plasma drug concentration with a low risk of toxicity. Drugs, which are locally active in the stomach, drugs having narrow absorption window and unstable in the intestine, and colonic environment, are the potential drug candidates. The approach not only improves drug absorption but also minimizes the mucosal irritation of drugs. As the approach requires a high fluid level in the stomach to float and work efficiently, it makes the approach limited up to some extent. Many buoyant systems have been developed based on granules, powders, capsules, tablets, laminated films, and hollow microspheres and few formulations have been commercialized in the market at the present time. This review gives an overview of the approach of floating drug delivery at present with sequential demystification thus enabling a greater understanding of their role in medicine and drug delivery.

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Section: Physiology Of Stomachmentioning

confidence: 99%

Untitled

2020

IJPBA

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“…The polymers in Madopar HBS are hydroxylpropylmethylcellulose (HPMC) and gelatin (Sabale et al, 2010;Roche, 2010) while that of Sinemet CR are hydroxypropylcellulose and HPMC (Merck Sharp & Dohme Corp., 2014). IPB is a blend of interpolyelectrolyte complex (a merge of molecular weights of two polymers) and a polysaccharide.…”

Section: Comparative In Vitro Drug Release Studiesmentioning

confidence: 99%

An optimized gastroretentive nanosystem for the delivery of levodopa

Ngwuluka

Choonara

Kumar

et al. 2015

International Journal of Pharmaceutics

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“…On April 1, 2017, the issues of improving the quality of medical services in order to control the state of the prices for paid and free medical services in the country and ensure their provision by the state medical and preventive institutions on April 1, 2017 It is reflected in the Decree of the President of the Republic of Uzbekistan № PP-2863 "About measures for further development of the private sector in the health sector", adopted by the President Sh.M. Mirziyoyev [6].…”

Section: Introductionmentioning

confidence: 99%

Study of the Experience of Foreign Countries in the Development of Medical Services Market in Uzbekistan

2020

jcr

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This article describes the current state of the medical services market in the context of innovative economy development In addition, measures to ensure the quality, efficiency and affordability of guaranteed health services have been studied and in-depth analysis of market systems of medical services in developed countries. The study investigated many theories of economists in foreign countries, especially in analyzing the market for medical services.

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Formulation and evaluation of floating dosage forms: An overview

Cited by 12 publications

References 52 publications

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An optimized gastroretentive nanosystem for the delivery of levodopa

Study of the Experience of Foreign Countries in the Development of Medical Services Market in Uzbekistan

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