Formulation and Evaluation of Garlic Powder Loaded Floating Matrix Tablet

Abstract

Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers.
 Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour.
 Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT.
 Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.

An Exploratory Analysis of the Stability and Quality of Instant Soup Mix Powder Incorporated with Malabar Spinach Leaves Powder under Refrigerated Conditions

“…Tomatoes, garlic, and onion powder were used as ingredient for preparation of instant soup mix. Tomatoes, garlic, and onion were washed under running water for removal of dust, dirt and other foreign material, and processed into powder from by using standard methods of Srivastava [4], Pawar [5], and Sangwan (2010), respectively.…”

Development and Evaluation of Self Micro-Emulsifying Formulation of Venlafaxine HCl with Improved Antidepressant Activity

“…14 Furthermore, self-emulsifying formulations typically provide greater drug loading capacity than other lipid-based formulations since the solubility of drugs with intermediate partition coefficients (logP value between 2 to 4) is usually low in natural oils but higher in co-solvents, amphiphilic surfactants, co-surfactants and their mixtures. 15,16 Considering the intermediate logP (2 to 4) and low oral bioavailability of VEN, formulation of SMEDDS seems to be an appropriate technique for increasing solubility and bioavailability of the drug. Thus, the aim of study is formulation of SMEDDS of VEN and evaluation of its performance in vivo.…”

“…During each sample removal, an equivalent amount of fresh dissolution media was replaced to maintain the sink condition. 5,16 In vivo study of self-microemulsifying formulations [38][39][40] For studying the in vivo performance of SMEDDS formulations, antidepressant and anti-anxiety activity of the developed formulations were evaluated using forced swim test and EPM…”

A study on development cum standardization of instant soup mix using Malabar Spinach (Basella alba) leaves powder

“…Tomatoes, garlic, and onion powder were used as ingredient for preparation of instant soup mix. Tomatoes, garlic, and onion were washed under running water for removal of dust, dirt and other foreign material, and processed into powder from by using standard methods of Srivastava (2010) [22] , Pawar (2019) [15] , and Sangwan (2010) [18] , respectively.…”