Formulation and Evaluation of Herbal Oil-Based Itraconazole Cream for Fungal Infection

Kumar, Inder; Thakur, Bhumika; Sharma, Ankita; Thakur, Reena

doi:10.22159/ajpcr.2020.v13i11.39172

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…The cumulative percentage medication release was determined by utilising the calibration curve of diacerein. The drug release profile from the gels was determined by plotting the in vitro drug release data and fitting it into different mathematical models to determine the mechanism of drug release (Kumar et al, 2011;Aziz et al, 2018;Kumar and Kumar, 2021).…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Anasuya,

Srinivasa Rao,

Abhijeet

et al. 2024

Intern. J. Zool. Invest.

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The primary aim of the present study was to develop and assess a topical gel containing Diacerein-loaded transferosomes in order to address the limitations of oral administration of Diacerein in the treatment of Osteoarthritis. Osteoarthritis, the prevailing kind of arthritis, is the primary cause of disability and lacks effective symptomatic treatment options. Diacerein hinders the interaction with the function of interleukin 1-β and is beneficial in the palliative management of osteoarthritis, while it also induces diarrhoea when taken orally. Diacerein is rapidly eliminated from the body since it has a short half-life. Therefore, a sustained release formulation is necessary for long-term administration in order to enhance patient adherence. Osteoarthritis, unlike other joint disorders, specifically affects one or a few joints. This characteristic allows for targeted Intra-articular treatment, minimising the potential for systemic adverse effects. An enhanced delivery mechanism is urgently required to enhance bioavailability and mitigate drug-related toxicity and the inefficacy of anti-inflammatory medicines. An investigation was conducted to assess the efficacy of Diacerein in situ gel as a potential treatment for Osteoarthritis. The formulation consists of poloxamer 407 as the primary polymer, hydroxypropyl methylcellulose K4, and carbopol 934 as the copolymer. It is manufactured using the conventional cold technique and is distinguished by multiple properties. All characterizations yielded satisfactory outcomes. The drug release is conducted in vitro using a phosphate buffer solution with a pH of 7.4, which indicates a regulated release of the medication.

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Section: In Vitro Drug Releasementioning

confidence: 99%

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Anasuya,

Srinivasa Rao,

Abhijeet

et al. 2024

Intern. J. Zool. Invest.

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“…It has the best blood-purifying properties, hence it is utilised in any illnesses with blood impurities as their cause. Haridra is a skin rejuvenator and revitalizer that slows down the appearance of wrinkles 8 .…”

Section: Figure 2 -Sandalwood Turmericmentioning

confidence: 99%

Formulation and Evaluation of Herbal Face Pack

2023

IJFMR

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The goal of this work is to create and assess a herbal face pack for cosmetic use using natural ingredients from the local market, including multani mitti, turmeric, aloe vera, sandalwood, lemon peel, rose petal powder, manjistha, lodhra, and gramme flour. These ingredients were dried, powdered, then passed through sieve 120, mixed geometrically, and evaluated for their organoleptic and physico-chemical, general powder, microscopical characters, The mixed dry powder exhibited satisfactory flow characteristics, making it appropriate for a face pack. The powder's particle size was determined to be 21.5 - 2.10 m.The mixed dry powder's microscopical characteristics were observed. Herbal face packs or masks are applied to the face to increase blood flow, revitalise the muscles, preserve the suppleness of the skin, and clean out skin pores. Herbal cosmetics have the benefit of being nontoxic, reducing allergic responses, and containing substances that have a long history of being effective. Therefore, in the current work, we discovered favourable qualities for face packs, and more optimisation studies are needed on this study to uncover the beneficial uses of face packs for human usage as cosmetics.

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“…The prepared topical cream was visually inspected for homogeneity, colour, odour, state, consistency, and texture. 7,8 For pH determination, 5 gm of the formulated cream was mixed in 50 ml distilled water and measured by using pH meter at 27 °C.…”

Section: Physical Appearance 78mentioning

confidence: 99%

Formulation and Evaluation of Herbal Excipients-Based Ketoconazole Cream for Fungal Infection

Patel,

Gajera,

Shah

et al. 2023

JNR

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The goals of the current studies were to create herbal excipients-based ketoconazole cream to enhance the efficacy against chronic mucocutaneous candidiasis. Ketoconazole, coconut oil and other herbal excipients namely shea butter, bees wax, Lanolin and Rose oil were used for the formulation. Each formulation was prepared with various concentrations of coconut oil. Every prepared formulations were evaluated successfully. Among all the formulations F4 was the best that exhibiting a higher in vitro diffusion rate 59.6 ± 0.10 % CDR within 480 min with maximum antifungal efficacy, compared with the marketed formulation. We might therefore say that herbal excipients-based cream improved patient compliance and is a superior alternative to oral preparation, easier administration, local bioavailability, and better results for individuals with persistent mucocutaneous candidiasis who are afflicted with fungi.

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Formulation and Evaluation of Herbal Oil-Based Itraconazole Cream for Fungal Infection

Cited by 7 publications

References 22 publications

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Formulation and Evaluation of Herbal Face Pack

Formulation and Evaluation of Herbal Excipients-Based Ketoconazole Cream for Fungal Infection

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