Formulation and Evaluation of Isorhamnetin Loaded Poly Lactic-Co-Glycolic Acid Nanoparticles

Settu, Kandakumar; Vaiyapuri, Manju

doi:10.22159/ajpcr.2017.v10i11.19918

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…For the development of nanotherapeutics, nanoparticles are characterized using different techniques [ 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 ]. Sufficient knowledge of the safety, efficacy, and quality of nanotherapies is required to enable easy translation toward clinical applications [ 211 ].…”

Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) and long-term illness consequences. They may be associated with inflammatory processes due to cellular oxidative stress and an imbalanced antioxidant system. The ability of phytochemicals with antioxidant and anti-inflammatory activities, such as Ginkgo biloba, to alleviate neurological complications and brain tissue damage has attracted strong ongoing interest in the neurotherapeutic management of long COVID. Ginkgo biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, and luteolin. They have various pharmacological and medicinal effects, including memory and cognitive improvement. Ginkgo biloba, through its anti-apoptotic, antioxidant, and anti-inflammatory activities, impacts cognitive function and other illness conditions like those in long COVID. While preclinical research on the antioxidant therapies for neuroprotection has shown promising results, clinical translation remains slow due to several challenges (e.g., low drug bioavailability, limited half-life, instability, restricted delivery to target tissues, and poor antioxidant capacity). This review emphasizes the advantages of nanotherapies using nanoparticle drug delivery approaches to overcome these challenges. Various experimental techniques shed light on the molecular mechanisms underlying the oxidative stress response in the nervous system and help comprehend the pathophysiology of the neurological sequelae of SARS-CoV-2 infection. To develop novel therapeutic agents and drug delivery systems, several methods for mimicking oxidative stress conditions have been used (e.g., lipid peroxidation products, mitochondrial respiratory chain inhibitors, and models of ischemic brain damage). We hypothesize the beneficial effects of EGb in the neurotherapeutic management of long-term COVID-19 symptoms, evaluated using either in vitro cellular or in vivo animal models of oxidative stress.

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Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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“…However, its targeting capacity is poor due to the poor aqueous solubility and bioavailability, which proves the necessity for the development of the nanoformulations for the most eligible flavonoid molecule in the treatment of cancer. [58] studied the effect of poly lactic-co-glycolic acid isorhamnetin nanoparticles on HepG2 cancer cell lines. They concluded that the nanoformulation of isorhamnetin resulted in a substantial increase in the inhibition of proliferation as compared to the plain isorhamnetin.…”

Section: Isorhamnetinmentioning

confidence: 99%

Nanoparticle Formulation of Bioflavonoids for Enhanced Anti-Cancer Activity

et al. 2020

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Among the natural sources, plant origin drugs constitute around 25% which includes various secondary metabolites such as bioflavonoids, alkaloids, terpenes, saponins, glucosides, and lignans. The bioflavonoids belonging to the polyphenol group shows many beneficial effects like hepatoprotective, antioxidant, antibacterial, anticancer, anti-inflammatory and antiviral. The main objective of this article is to collectively present the research data published worldwide about the anticancer activity of bioflavonoids by loading them in novel formulations. Thus, the present review explored the novel formulations of the bioflavonoids with improved pharmacokinetic properties along with the enhanced anticancer activity. The major drawback with bioflavonoids is its poor solubility and bioavailability, which restricts the usage of bioflavonoids in the treatment of cancer in the market worldwide. Novel drug delivery system seems to possess many benefits like site-specific drug delivery along with minimal side effects and improves pharmaceutical and therapeutic properties of drugs compared to a conventional dosage form of bioflavonoids. The scope for improvement of anticancer activity of bioflavonoids by incorporating in novel pharmaceutical formulations like nanoparticles is very high, and it has to be considered as a potential area of research.

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“…In the prolonged-release dosage form, pasireotide pamoate (10, 20 mg, 30, 40 mg or 60 mg) is evenly distributed among biodegradable microspheres based on poly-D, Llactide-co-glycolide (PLGA). Both copolymers belong to the wellknown family of biocompatible poly (D, L-lactide-co-glycolide) copolymers, which are used for many years in similar commercial drugs [52][53][54]. They consist of lactide and glycolide, which are forming blocks, and degraded to lactic and glycolic acids, physiological to the body and metabolized by normal physiological pathways, and suitable for use in humans for parenteral administration.…”

Section: Pasireotide-ssa With Universal Binding Profilementioning

confidence: 99%

Somatostatin Analogues for the Treatment of Neuroendocrine Tumours. Dosage Forms and Routes of Administration (Review)

Shprakh¹

2020

Int J App Pharm

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This review summarises information on drug products Somatostatin Analogues (SSAs), which are included in the algorithm of Neuroendocrine Tumors (NET) treatment. SSAs are the current standard for safe and effective management of NET symptoms and control of tumours growth and are administered in a range of dosage forms for parenteral administration, such as intramuscular, subcutaneous and implant. A search criterion was the therapy of NET with medicines from a group of SSAs. Literature survey has been done in a range of years 1990-2018 to make the review updated and comprehensive and to show the development of SSAs new pharmaceutical dosage forms to improve patient quality of life and side effects decrease. The sources were world-recognized journals. Keywords used as filters were NET, SSAs, octreotide, lanreotide, pasireotide, Somatostatin Receptors (SSTR), dosage form. The current review is created with an intended to focus on the advantage of SSAs modern dosage forms. Literature survey revealed that many studies were carried out to SSAs encapsulation into microspheres that changes the drug bioavailability and allows reducing the number of administration. Also, SSAs delivery systems in particular devices such as auto-injector have been created to control the continuous concentration of the drug and to provide safety guarantee. Besides, studies have been carried out to prepare SSAs formulations for oral administration to improve the quality of life of the NET patients. In this review, SSAs pharmaceutical dosage forms with improved pharmacokinetic and therapeutic characteristics and routes of administration are analyzed.

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Formulation and Evaluation of Isorhamnetin Loaded Poly Lactic-Co-Glycolic Acid Nanoparticles

Cited by 4 publications

References 35 publications

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Nanoparticle Formulation of Bioflavonoids for Enhanced Anti-Cancer Activity

Somatostatin Analogues for the Treatment of Neuroendocrine Tumours. Dosage Forms and Routes of Administration (Review)

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