Formulation and Evaluation of Ketoprofen Trilayered Matrix Tablet

Abstract

The aim of the present work is to design and evaluate the controlled release Ketoprofentrilayered matrix tablets, to release the drug for prolonged period of time, which follows zero order kinetics by maintaining a constant drug level in the plasma. Formulations were prepared by using different ratios of polymers like Hydroxy propyl methyl cellulose (K100 &6 cps) and Ethyl cellulose. The FTIR analysis assured compatibility of drug and excipients. Trilayered tablets containing middle drug core layer and either side of core layer, a barrier polymer layers present, prepared by wet granulation method. After formulation development, the trilayered tablets were evaluated for their appearance, hardness, friability, weight variation, disintegration time, assay, in-vitro drug release and stability studies. Core granuleswhich have shown the desired drug release were selected to prepare the trilayered matrix tablets. Based on the evaluation studies FF8 formulation was optimized. FF8 showed in-vitro drug release of 95.8% for 24h which is shown to have better release than marketed preparation hence considered as most promising preparation. Drug release values of optimized formulation (FF8) were subjected to mathematical kinetic modeling, and the correlation coefficient (R 2 ) values drug release follows zero-order (0.994) kinetics and mechanism of dug release is by KorresmayerPeppas model (0.993). FF8 formulation subjected for accelerated stability study for 3 months and the formulation was found to be stable during the study period.

Formulation, Optimization and Evaluation of Gastroretentive Alginate Beads of Ivacaftor by Using Factorial Design

“…The formulation table of ivacaftor solid dispersion was shown in table-1. The best formulation was selected based upon invitro dissolution studies [11][12][13].…”