Formulation and Evaluation of Lansoprazole Floating Tablets

Abstract

Floating tablets were designed to prolong the gastric residence time after oral administration and to achieve controlled release of Lansoprazole to treat gastric ulcers. A combination of effervescent and noneffervescent mechanism is used. HPMC (Hydroxy propyl methyl cellulose) was used as swelling polymer and sodium bicarbonate as gas generating agent to reduce the floating lag time. Floating tablets with varying proportions of sodium bicarbonate and HPMC were prepared. The prepared formulations were evaluated for various tablet and floating parameters. Tablet properties were found to be within the limits according to procedures prescribed in USP. They had a floating lag time around 3-7 seconds and floating time more than 24 hours. The cumulative % drug release in simulated gastric fluids after 10 hours was 70% -95%. The mechanism of drug release was analyzed by fitting the release data into various kinetic models. It was found that all the formulations best fit the Higuchi's model.

Phytochemical Analysis of Cold Toluene Extracts of Piper nigrum and its Antibacterial and Antifungal Activity

“…The shiny pale yellow crystals (m. p. 132°C) obtained from toluene extract of Piper nigrum fruits is found to be an alkaloid on performing Mayer's reagent test [8][9][10] . The molecular formula was established as C 17 H 19 O 3 N by Agilent, 6540 Q-TOF (HRMS) mass spectrometer 8 and the TLC of the pure crystals showed Rf value 0.23 which is very close to standard Rf value of piperine, reported in literature that is 0.25 4 , thus crystals obtained may be of piperine.…”

“…The in vitro antimicrobial activity of toluene extracts of pepper were checked by disc diffusion method 10 . Bacterial culture in log phase was inoculated in nutrient agar and plated.…”

Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems

“…Samples diluted suitably with pH 6.8 Phosphate buffer and measured at 225 nm by using UV. Absorbance was used for quantification of drug release [48][49][50] .…”