Formulation and Evaluation of Liquisolid Compacts of Lornoxicam

Mokashi, Asma A.; Gaikwad, Snehalata L.

doi:10.22159/ijpps.2019v11i6.28328

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…When, sonication time increase from 30 to 90 second, then PDI was 0.309, 0.189 and 0.487, respectively for different NLCs formulations. It was observed that on 90 second of sonication time the PDI was increased and it was due to the high mechanical forced of sonication waves which were resultant in heat generation which leads to agglomerates or denaturing the lipid molecules after breaking the particles [19][20][21][22]. Value represent as mean±SD (n=6)…”

Section: Resultsmentioning

confidence: 99%

Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Majumdar

Dubey

2019

Int J App Pharm

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Objective: The aim of the present study is to develop docetaxel-loaded nano liquid crystals (NLCs) to enhanced and effective delivery of the drug to the skin cancer. Methods: NLCs bearing docetaxel were prepared by an emulsification solvent diffusion method. The formulated NLCs were characterized for average particle size, polydispersity index (PDI) Zeta potential, entrapment efficiency and in vitro drug release study. The prepared formulations were studied for it's in vitro cell line and cell uptake study. Results: It was revealed that the average size of NLCs was found 178.3±5.07, PDI was 0.189, percent entrapment efficiency was found 71.3±2.49 and Zeta potential was found-17.3±2.4. In vitro release determined by Franz diffusion cell was found 61.6±3.2% after 72 hr. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay shows that Docetaxel loaded NLCs were giving more cytotoxicity as compared to the plain drug. The cell uptake study was found enhanced uptake of fluorescein isothiocyanate (FITC) loaded NLCs in comparison to plain FITC. Docetaxel and docetaxel-loaded NLCs showed 28.3±0.3 and 39.3±1.3 growth inhibition respectively after 48h upon incubation at 0.5 µg/ml concentration (p<0.05). Conclusion: The result of the studies was concluded that NLCs can be used as impending drug delivery system which may enhance the drug uptake and maintain the drug level for longer period of time and it is potential carrier system which can be used for the treatment of skin diseases like cancer.

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Section: Resultsmentioning

confidence: 99%

Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Majumdar

Dubey

2019

Int J App Pharm

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“…About 5 ml of eluted sample was withdrawn at specified time intervals, filtered, and replaced with an equivalent amount of buffer into the vessel. The samples were suitably diluted and analyzed for Palbociclib using UV method spectrophotometrically at 220 nm [14].…”

Section: In Vitro Drug Dissolution Of Palbociclib Ssd'smentioning

confidence: 99%

Formulation, in Vitro and in Vivo Evaluation of Palbociclib Solid Dispersions

APARNA

RAO²

2022

Int J App Pharm

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Objective: The current research is aimed to enhance the dissolution and bioavailability of Palbociclib by formulating into solid dispersion Methods: The Palbociclib solid dispersions (SD) prepared by adopting different methods: Surface solid dispersion technique (SSD1-SSD15), Melt granulation (MG1-MG15) and Liquisolid compacts (LSC1-LSC9). All formulations were evaluated for physico-chemical parameters followed by in vitro dissolution studies. The optimised formulation was subjected to bioavailability studies in rats. Results: The results indicated that the prepared formulation satisfactory results for all the evaluated parameters. The SD formulations prepared by liquisolid compact and Melt Granulation technique (LSC1 and MG 3) displayed maximum dissolution of 99.64% and 99.58%. The FTIR of LSC1 displayed no interaction among drug and excipients while XRD, SEM displayed amorphous nature of drug in formulation. The stability study results indicated that LSC 1 was stable over 3 mo. The in vivo bioavailability studies conducted on rats indicate that at any time point, the drug plasma concentrations in animals administrated with the SD formulation was higher than pure drug. The Cmax of the palbociclib SD was 970.76±1.22 ng/ml and was significant (p<0.05) when compared to pure drug suspension formulation (105.84±0.19 ng/ml). The Tmax of both SD formulation and pure drug were 2.0±0.04 and 4±0.01 h, respectively. The AUC0-∞ for SD was higher 7816.61±1.37 ng. h/ml) than the pure drug suspension 2501.4±1.46 ng. h/ml indicating better systemic drug absorption from SD formulation prepared using Melt granulation technique. Conclusion: A significant enhancement in vitro dissolution profile and bioavailability of the melt granules was observed compared to the pure Palbocicilib and marketed product.

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“…Consequently, a dry, free-flowing, and compressible powder is obtained [6]. This technology is initially used in the purpose of improving drug solubility of poorly water-soluble drugs by using water-soluble polymer [7][8][9]. However, this method has been developed and the same principle was utilised to prepare sustained release formulation using hydrophobic polymers [5,10].…”

Section: Introductionmentioning

confidence: 99%

Development of Liquisolid Formulation for Improved Sustained Release of Propranolol Hydrochloride

et al. 2021

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Objective: The aim of this study was to develop a liquisolid formulation of propranolol hydrochloride to obtain an improved sustained release profile by varying the ratio of liquid vehicles. Methods: In this study, propranolol hydrochloride (PPH) was dispersed in the combination of propylene glycol and polysorbate 80, as the liquid vehicles, with different ratios. Eudragit® RL and Aerosil® were used as carrier and coating materials, respectively, to produce a dry and free-flowing powder. In addition, HPMC was used to amplify the retardation effect. The prepared formulations were evaluated for its physicochemical properties, including loss on drying, flow rate, angle of repose calculation, drug content analysis, FT-IR spectroscopy, as well as dissolution studies. The obtained dissolution profiles were subsequently fitted to the mathematical model in order to determine the drug kinetics. Results: The results show that all formulations performed dry and free-flowing granules containing PPH in the range of 7-9%. Furthermore, all the prepared formulations were able to sustain the drug release for a total of 8 h in two different dissolution media, namely simulated gastric fluid and simulated intestinal fluid. F4 containing propylene glycol and polysorbate 80 (1:2) possessed the lowest drug release rate. It was also obtained that F1 and F3 followed first-order kinetics while F2, F4, and F5 complied with the Higuchi model. Conclusion: Overall, there was no difference in all the dissolution profiles based on the calculation of the difference and similarities factor.

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Formulation and Evaluation of Liquisolid Compacts of Lornoxicam

Cited by 3 publications

References 10 publications

Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Formulation, in Vitro and in Vivo Evaluation of Palbociclib Solid Dispersions

Development of Liquisolid Formulation for Improved Sustained Release of Propranolol Hydrochloride

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