Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets

Abstract

This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.

Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

“…Before starting the SeDeM-ODT characterization, Differential Scanning Calorimetry (DSC) and Fourier Transform-Infrared (FTIR) spectroscopy studies were conducted to observe the eventual analytical incompatibilities ( Moisei et al, 2014 , Todoran et al, 2018 , Rus et al, 2019 ). To obtain orodispersible tablets, excipients from various classes are needed ( Alejandro et al, 2020 , Tawfeek et al, 2020 ). In this study excipients from different classes were used, and the compatibility of each excipient with CBD by the means of a binary system (1:1) using DSC and FTIR analysis has been evaluated.…”

“…Developing CBD-ODT represents an opportunity taking into consideration the reduced number of pharmaceutical formulations with CBD that can be found on the market. Other drugs that are already present on the pharmaceutical market or were used to obtain orodispersible tablets are loperamide, sulpiride, desloratadine, loratadine, olanzapine, some of them having also solubility issues just as CBD (desloratadine and loratadine) ( Alejandro et al, 2020 , Tawfeek et al, 2020 , Novick et al, 2017 , Montgomery et al, 2012 ). Taking into consideration the palatability, the use of flavouring and sweetener agents needs to be considered when developing a new formulation ( Desai et al, 2020 , Casian et al, 2018 ).…”

Controllable Solid Electrolyte Interphase by Ionic Environment Regulation for Stable Zn‐Ion Battery

“…The broad and intense absorption peak observed ≈3200 cm −1 in both PA2‐Zn and PA4‐Zn can be attributed to the intermolecular and intramolecular O–H stretching vibration. [ 31–33 ] Additionally, the ─OH characteristic peaks of PA7‐Zn, PA10‐Zn, and PA12‐Zn exhibited a redshift, suggesting the presence of hydrogen bonding interactions involving ─OH groups or uncoordinated functional groups. [ 34,35 ] Compared with PA7‐Zn, PA10‐Zn and PA12‐Zn, an absorption peak for C═O was detected in the PA2‐Zn and PA4‐Zn at 1650 cm −1 , [ 36,37 ] indicating the existence of PA on the Zn anodes.…”

Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats

“…FMT F7 was cut transversely, and the internal matrix texture was examined at a voltage of 20 kv. Cross-section samples were prepared by cutting a thin slice of the FMT using a scalpel (Alejandro et al., 2020 ; ElMeshad et al., 2020 ; Naveen et al., 2020 ; Sheta et al., 2020 ).…”