FORMULATION AND EVALUATION OF &lt;i&gt;FICUS BENGHALENSIS&lt;/i&gt; AND &lt;i&gt;FICUS RACEMOSA&lt;/i&gt; AQUOUES EXTRACTS

Murti,

doi:10.3844/ajbbsp.2013.219.223

Cited by 1 publication

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“…An ancient Indian mythological book writes “A decoction of leaf buds and aerial roots of F. benghalensis , mixed with honey, can be given for any burning sensation.”[ 6 ] It has also been recommended for rheumatism and skin disorders such as sores. [ 7 ] The bark is considered useful in burning sensation, ulcers, and painful skin diseases. [ 8 ] It can be used in inflammation and toothache.…”

Section: Introductionmentioning

confidence: 99%

Effect of root-extracts of Ficus benghalensis (Banyan) in pain in animal models

Panday

Rauniar

2016

Journal of Neurosciences in Rural Practice

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Introduction:According to the WHO, 70–80% population in developing countries still relies on nonconventional medicine mainly of herbal origin. Even in developed countries, use of herbal medicine is growing each year. Pain is an unpleasant feeling often caused by intense or damaging stimuli. Traditionally, different plant parts of Ficus benghalensis are claimed to have several analgesic properties. Few scientific evidences support these uses. Interestingly, still others contradict these uses. It was shocking to find very scarce scientific studies trying to solve the mystery.Materials and Methods:It was a quantitative experimental study in Swiss albino mice of either sex. Sample size was calculated using free sample size calculating software G*Power version 3.1.9.2. Hot-plate test and tail-flick test were central antinociceptive paradigms. Writhing test was peripheral model for pain. Test drugs were aqueous root extracts of F. benghalensis at 100 mg/kg and 200 mg/kg mouse weight prepared by Soxhlet method. Suitable negative and positive controls were used. The experimental results were represented as mean ± standard deviation statistical level of significance was set at P < 0.05. For calculation, parametric test - one-way analysis of variance (ANOVA) or nonparametric test - Mann–Whitney U-test was appropriately used.Results:Hot-plate reaction time at 100 mg/kg (13.64 ± 1.30 s) and 200 mg/kg (10.32 ± 2.23 s) were nonsignificant (P = 0.425 and P = 0.498, respectively) compared to negative control (11.87 ± 1.92 s). One-way ANOVA revealed nonsignificant (P = 0.178) between-group comparison in mean tail-flick reaction time. Test drug at 200 mg/kg produced statistically significant more writhing (36.00 ± 14.85 in 10 min) than negative control, normal saline (11.83 ± 12.43 in 10 min) or the positive control, Indomethacin (3.50 ± 5.21 in 10 min), P value being 0.031 and 0.003, respectively.Conclusion:Aqueous root extracts of F. benghalensis at 200 mg/kg produces statistically significant writhing.

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Section: Introductionmentioning

confidence: 99%