Formulation and Evaluation of Mesoporous Silica Nanoparticle Loaded Fast Dissolving Tablet of Tamoxifen

Jadhav, Vaishali

doi:10.36468/pharmaceutical-sciences.746

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Namely, Rengajaran et al were able to derive that molecules residing in pores less than 10 times their size remains in amorphous forms due to not having the space to form crystals [ 156 ]. This phenomenon has been utilized in the formulation of orodispersable films (prednisolone) [ 157 ], fast dissolving tablets (tamoxifen) [ 158 ], and lyophilized tablets (silymarin) [ 159 , 160 ]. In one in vivo study, spherical mesoporous silica nanoparticles (MSNs) were developed by Zhang et al as an oral drug delivery system to enhance the oral bioavailability of the drug telmisartan (TEL).…”

Section: Nanotechnological Approaches For Solubility Enhancementmentioning

confidence: 99%

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Kumari

Choudhari

Patel

et al. 2023

Life

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A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the problem of poor solubility. This review article attempts to summarize several conventional methods utilized to increase the solubility of poorly soluble drugs. These methods include the principles of physical and chemical approaches such as particle size reduction, solid dispersion, supercritical fluid technology, cryogenic technology, inclusion complex formation techniques, and floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use of co-solvents, hydrotrophy, polymorphs, amorphous solid dispersions, and pH variation). Various nanotechnological approaches such as liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, and so forth have also been widely investigated for solubility enhancement. All these approaches have brought forward the enhancement of the bioavailability of orally administered drugs by improving the solubility of poorly water-soluble drugs. However, the solubility issues have not been completely resolved, owing to several challenges associated with current approaches, such as reproducibility in large scale production. Considering that there is no universal approach for solving solubility issues, more research is needed to simplify the existing technologies, which could increase the number of commercially available products employing these techniques.

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Section: Nanotechnological Approaches For Solubility Enhancementmentioning

confidence: 99%

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Kumari

Choudhari

Patel

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Notably, Rengajaran et al deduced that molecules residing in pores less than 10 times their size remain in amorphous forms due to insufficient space for crystallization [106] . Exploiting this phenomenon has led to the formulation of orodispersible films (e.g., prednisolone) [107] , fastdissolving tablets (e.g., tamoxifen) [108] , and lyophilized tablets (e.g., silymarin) [109][110] .…”

Section: Mesoporous Silicamentioning

confidence: 99%

Exploration of Solubilization Strategies: Enhancing Bioavailability for Low Solubility Drugs

G. K.,

2023

ijnrph

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This review explores various strategies aimed at improving the solubilization of low-solubility drugs, including formulation design, nanoparticle technologies, prodrug strategies, and particle size reduction methods. Water solubility plays a crucial role in shaping bioavailability, formulation strategies, and therapeutic efficacy. Nanotechnology, particularly in nanomedicines, is a promising avenue to tackle solubility challenges, but faces barriers like production costs, formulation reproducibility, and varying pharmacokinetics. Despite these challenges, the burgeoning landscape of innovative drug delivery technologies offers advantages, particularly for formulation scientists. Understanding molecular properties is crucial for resolving these challenges, with solid dispersions and lipid-based delivery techniques emerging as sought-after solutions. Commercializing these advancements requires a leap in technology and infrastructure, making it essential to streamline the process and identify optimal approaches. Pioneering methodologies, such as Fagerholm's predictive model for human oral bioavailability based on chemical structure, demonstrate promising predictive accuracy. The integration of artificial intelligence and innovative solubility enhancement technologies is pivotal in transforming drug delivery, tackling solubility concerns, and streamlining research and development expenses.

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CuS-NPs, GQD, MSN-NPs and Doxorubicin: An excellent nano-compound for cancer treatment by chemo-photodynamic therapy

Gharibzadeh,

shirkani,

Karimi

et al. 2024

Journal of Alloys and Compounds

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Formulation and Evaluation of Mesoporous Silica Nanoparticle Loaded Fast Dissolving Tablet of Tamoxifen

Cited by 3 publications

References 10 publications

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Exploration of Solubilization Strategies: Enhancing Bioavailability for Low Solubility Drugs

CuS-NPs, GQD, MSN-NPs and Doxorubicin: An excellent nano-compound for cancer treatment by chemo-photodynamic therapy

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