Formulation and evaluation of mucoadhesive buccal films of enalapril maleate

Abstract

Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesive drug delivery system of enalapril maleate were prepared as buccal films, by solvent casting technique. Sodium carboxymethylcellulose, hydroxylpropylmethylcellulose, hydroxyethylcellulose and polyvinyl pyrrolidone K-90 were used as mucoadhesive polymers. Prepared films were evaluated for their weight, thickness, surface pH, swelling index, drug content uniformity, in vitro residence time, folding endurance in vitro release and permeation studies. Films exhibited controlled release over more than 10 h in permeation studies. It was concluded that the films containing 20 mg of enalapril maleate in sodium carboxymethylcellulose 2% w/v and hydroxyethyl cellulose 2% w/v (formulation F5), showed good swelling, a convenient residence time and promising controlled drug release, thus can be selected for the development of buccal film for effective therapeutic uses.

Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide

“…The swelling rate of buccoadhesive discs was evaluated by placing the accurately weighed discs (W 1 ) in 50 ml phosphate buffer solution (pH 6.8) at 37 °C. Swelling was measured at predetermined time intervals (15,30,60, 90 and 120 min). Then the discs were removed from the beaker after carefully removing the excess surface water using the filter paper.…”

“…Then swollen film diameter was re-measured (D 2 ) at regular intervals (up to 1 h) and the swelling index was calculated using the following formula: 14,15 Swelling index = D2-D1/D1…”

Development and Evaluation of Polymer-bound Glibenclamide Oral Thin Film

“…Increase in weight of the film was determined at every time interval until a constant weight was subsequently found. The swelling percentage was calculated by using the following formula [28,29].…”

Dental Mold: A Novel Formulation to Treat Common Dental Disorders

“…At predetermined time intervals (1-5 h), increase in weights (wet weight) was reported after removal of excess saliva with filter paper. When the weight became constant (W t ), percent swelling was calculated in terms of water uptake (27,28).…”