Formulation and evaluation of n-acetyl cysteine loaded bi-polymeric physically crosslinked hydrogel with antibacterial and antioxidant activity for diabetic wound dressing

Mondal, Sourav; Hazra, Ahana; Paul, Pankaj; Saha, Bishnu; Roy, Sanjita; Bhowmick, Pratibha; Bhowmick, Mithun

doi:10.1016/j.ijbiomac.2024.135418

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.135418

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Formulation and evaluation of n-acetyl cysteine loaded bi-polymeric physically crosslinked hydrogel with antibacterial and antioxidant activity for diabetic wound dressing

Sourav Mondal,

Ahana Hazra,

Pankaj Paul

et al.

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2024

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Fabrication and Characterizations of Microwave‐Assisted Gelatin Cross‐Linked LBG/Guar Gum–Based Super Porous Hydrogels With Metformin Hydrochloride for Open Incision Wound Healing

Dey,

Ruidas,

Hazra

et al. 2024

J of Applied Polymer Sci

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The goal of this study was to fabricate gelatin cross‐linked Locust bean gum (LBG)/guar gum–based hydrogels with microwave assistance for diabetic wound healing applications and evaluate it for physicochemical properties. In the last few years, microwave irradiation has gained acceptance as a reliable technique for quickening and streamlining chemically modified reactions. In order to achieve this, metformin‐loaded LBG and guar gum–based hydrogel were formulated employing microwave radiation. Moreover, the microwave‐assisted–based metformin hydrogel are microwave‐assisted reaction sudden increase in temperature may led to distortion of molecules, very vigorous and which may be hazardous, but environmental sustainability and friendly chemistry concepts are supported by microwave irradiation. The optimized formulation (F3) showed significantly improved physicochemical properties, with a swelling capacity of 480.4% ± 2.5%. The results indicate an appropriate duration for adequate drugs diffusion and nutrition exchange. Controlled disintegrate and sustained release of embedded drug molecules from F3 may have an impact on antibacterial activity. The study indicated that microwave‐assisted polymer blend hydrogels had adequately improved physical qualities, making them a promising candidate for improving diabetic wound healing and hastening skin tissue regeneration.

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Fabrication and Characterizations of Microwave‐Assisted Gelatin Cross‐Linked LBG/Guar Gum–Based Super Porous Hydrogels With Metformin Hydrochloride for Open Incision Wound Healing

Dey,

Ruidas,

Hazra

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

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Formulation and evaluation of n-acetyl cysteine loaded bi-polymeric physically crosslinked hydrogel with antibacterial and antioxidant activity for diabetic wound dressing

Cited by 1 publication

References 76 publications

Fabrication and Characterizations of Microwave‐Assisted Gelatin Cross‐Linked LBG/Guar Gum–Based Super Porous Hydrogels With Metformin Hydrochloride for Open Incision Wound Healing

Fabrication and Characterizations of Microwave‐Assisted Gelatin Cross‐Linked LBG/Guar Gum–Based Super Porous Hydrogels With Metformin Hydrochloride for Open Incision Wound Healing

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