Formulation and Evaluation of Niosomal Suspension of Cefixime

Nair, Sreeja C.; Kumar, B Abhilash; Krishna, Rakhi; Ps, Lakshmi; Vasudev, Deepa T

doi:10.22159/ajpcr.2017.v10i5.17189

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…Similar findings were reported by Kumar and coworkers presenting higher zone of inhibition with cephalosporin niosomes in contrast to the marketed formulation. 38 Thus, the CP proniosomes have been successfully obtained by this study is considered to be superior than conventional dosages owing to longer drug stay with controlled drug release and, improved stability and efficacy.…”

Section: Discussionmentioning

confidence: 88%

Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery

Saim¹,

Bashir²,

Naz³

et al. 2022

IJPER

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The role of Proniosomes in oral controlled drug delivery system is well accepted. Presently, an attempt was made to develop cephradine (CP) Proniosomes to prolong its duration of action with better efficacy. Overall, eighteen formulation trials were developed using variable quantities of sorbitol (F0S-F8S) and maltodextrin (F0M-F8M) carriers along with span60 and cholesterol. Trials were evaluated for powder flowability, drug entrapment efficiency and in vitro drug release. Based on the mentioned characteristics, formulations F4M and F4S were optimized. Stability test was performed on optimized Proniosomes for three months at temperature (2-8°C). Comparison for antimicrobial sensitivity against Staphylococcus aureus was also made between optimized and marketed conventional CP capsule. More than 80% drug release was observed in 22 hr in the trial formulations. The optimized CP Proniosomes were found to be highly stable with % drug entrapment efficiency of 78.60±0.15 and 88.41±0.19 respectively for F4M and F4S. The prepared Proniosomes possessed higher bactericidal activity against S. aureus than reference products (M1 and M2). In conclusion, CP Proniosomes have been successfully prepared using sorbitol/maltodextrin carrier. Sorbitol carrier exhibited marginally better drug entrapment efficiency and bactericidal activity than the maltodextrin trial and marketed brands. This effort offers improved drug delivery with the potential of more effective controlled therapy.

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Section: Discussionmentioning

confidence: 88%

Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery

Saim¹,

Bashir²,

Naz³

et al. 2022

IJPER

View full text Add to dashboard Cite

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“…The viscosity of alginate/HPMC mixtures affected the diameters and densities of beads and the volumes of entrapped drug substance. Alginate-chitosan beads increased in diameter with increasing chitosan concentrations, reflecting the formation of polyelectrolyte complexes between carboxyl groups of alginate and amine groups of chitosan [31][32][33][34]. Previous studies have shown that bead sizes are normally distributed over 50-2000 µm [35].…”

Section: Discussionmentioning

confidence: 95%

Unsuccessful Delivery of Tetrandrine From Colon-Targeted Dosage Forms Comprising Alginate/Hydroxypropyl Methylcellulose and Alginate–chitosan Beads

2018

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Objective: The objective of this study was to optimize the formulations of antifibrotic tetrandrine beads using alginate and various concentrations of hydroxypropyl methylcellulose (HPMC) and chitosan.Methods: Beads were formulated with six (F1-F6) concentrations of polymer and were then characterized using scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction; these beads were used for measurements of moisture contents, swelling, and in vitro drug release. Results:Beads with the highest concentrations of HPMC and chitosan produced the highest entrapment efficiencies of 49.83% and 50.71%, respectively. Moreover, drug release under stomach conditions (HCl pH 1.2 medium) was restricted to 75.01%, 61.01%, 51.86%, 74.84%, 66.00%, and 41.63% with increasing HPMC and chitosan concentrations (F1-F6, respectively). Conclusion:Beads of all formulations showed inadequate retention of tetrandrine under pH conditions of the upper gastrointestinal tract and would likely be unsuccessful as colon-targeted dosage forms.

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“…At low pressure, the rotatory evaporator was allowed to evaporate until a thin layer developed. The thin film was dried and dissolved in 20 mL of phosphate buffer, which was then placed in a water bath at 60ºC and rotated at 120 rpm to hydrate the layers [14,15,16,17].…”

Section: Methods Of Prepration Of Curcumin Niosomesmentioning

confidence: 99%

Niosomal Encapsulation of Curcumin: Formulation and Characterization

Singh

Upadhyay

2021

JPRI

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Aim: Because of its many actions, curcumin, a plant-derived polyphenolic substance found naturally in turmeric (Curcuma longa), has been the focus of a significant investigation. The utilization of safe, useful, and highly functional chemicals obtained from natural sources in human nutrition/prevention/therapy needs some modifications to achieve multifunctionality, enhance the bioavailability, and delivery methods, all to enhance their efficacy. Curcumin's limited water solubility, fast metabolism and removal from the body, and hence low bioavailability, are significant obstacles to its use. To address these issues, a variety of new drug delivery systems with multiple routes of administration have evolved. Encapsulating the medication in vesicular structures is one such technique that, if successful in enabling selective absorption, can be predicted to extend the drug's life in systemic circulation and reduce toxicity. As a result, several vesicular drug delivery methods, including liposomes, niosomes, transfersomes, and pharmacosomes, have been developed. Since then, developments in vesicular drug delivery have resulted in the creation of systems that enable drug targeting as well as the prolonged or controlled release of traditional medications. The present study aimed to develop and characterize curcumin-loaded niosomes. Design of Study: In present study 32 factorial method was used to formulate different formulations of niosomes containing curcumin. Place and Duration of Study: Department of Pharmacy, IFTM University Moradabad, From December to May 2021. Methodology: Various niosomal formulations of curcumin were developed by using surfactant and cholesterol by thin-film hydration technique. Total 9 formulations were developed and characterized (32 factorial designs). Results: Formulation N7 was considered as an optimized formulation since formulation F7 has maximum drug entrapment and a prolonged drug release rate. The present study suggests that the concentration of surfactant and cholesterol affects % drug loading efficiency of niosomes. The percentage entrapment efficiency of niosomes increases on the increasing concentration of surfactant (Span 60) and cholesterol but above a certain concentration of cholesterol further increment in cholesterol concentration reduces drug entrapment efficiency of niosomes.

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Formulation and Evaluation of Niosomal Suspension of Cefixime

Cited by 13 publications

References 7 publications

Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery

Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery

Unsuccessful Delivery of Tetrandrine From Colon-Targeted Dosage Forms Comprising Alginate/Hydroxypropyl Methylcellulose and Alginate–chitosan Beads

Niosomal Encapsulation of Curcumin: Formulation and Characterization

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