Formulation and evaluation of Ocimum sanctum Linn containing carboxymethylcellulose and sorbitol based hydrogel

Abstract

It is of interest to formulate a hydrogel consisting of Ocimum sanctum linn, sorbitol, and carboxymethyl cellulose and to evaluate the physical properties of the hydrogel. The hydrogel was prepared by dissolving Ocimum sanctum linn extract into the mixture containing sorbitol and carboxymethyl cellulose. The formulation was further evaluated for its swelling index, contact angle, in -vitro release properties, and surface analysis using atomic force microscopy. The swelling index showed a significant increase in weight from 1st hr to the 84th hour which is 11.1% and 15.8% respectively. The contact angle test showed a value of 72.81° and 75.99° respectively. In vitro drug release showed a burst release till the 6th day followed by a sustained release till the 20th day. Atomic force microscopy revealed smooth and consistent surface topography with a mean size of 51μm in diameter which depicts that the particles are well dispersed throughout the hydrogel matrix. Data show that hydrogel containing Ocimum sanctum linn extract, sorbitol, and carboxymethyl cellulose could be an efficient economic primeval substitute that is non-toxic, natural, and structured for clinical application.