Formulation and Evaluation of Oral Disintegrating Film of Atenolol

Sanjay, P.; N, Vishal Gupta; Dv, Gowda; Sivadasu, Praveen

doi:10.22159/ajpcr.2018.v11i8.26464

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Emesis not only affects the quality of life but can also lead to loss of many essential electrolytes from body. To overcome these difficulties, fast-dissolving film-type drug delivery system emerged as alternative way to deliver the drug [8]. The swallowing problem related to sold oral dosage forms can be elevated by formulating oral fast dissolving thin film, which disintegrates and dissolves rapidly after placing in the mouth without the need of drinking water.…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of Ramosetron Hydrochloride Mouth Dissolving Thin Film for Enhanced Therapeutic Efficacy and Palatability

GUNDE,

PIMPALE,

GAIKWAD

et al. 2023

Int J App Pharm

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Objective: Many people have difficulties in swallowing traditional dosage forms such as tablets and capsules. The goal of this study was to develop the mouth-dissolving thin film of Ramosetron HCl (RH) for quick onset of action in the treatment of vomiting and irritable bowel syndrome, with the added benefit of disguising the bitter taste of RH. Methods: The solvent-casting approach was employed to formulate mouth dissolving thin film. The effect of variable concentrations and different grades of hydrophilic polymer HPMC (E5, E15 and E50), and plasticizers like glycerol and PEG 400 on disintegration time, drug release, thickness, tensile strength, percent elongation, folding endurance, and on appearance were studied. The optimized batch was kept for stability study at40±2 °C/75±5% RH for 30 d. Results: The formed films were transparent with a smooth surface texture. The thickness, weight variation, drug content and pH of the surface were within acceptable limits. Tensile strength and folding endurance values demonstrated adequate mechanical strength. In 45 seconds, the formulation F6 comprising HPMC E5 (150 mg) and HPMC E15 (150 mg) with PEG 400 (0.4 ml) disintegrated. The F6 formulation released 98.78±0.96 %drug in 8 min and considered as optimal formulation. The taste masking of drug was evaluated by a taste perception study using volunteers. The optimized batch was found to be stable at 40±2 °C/75±5% RH for 30 d. Conclusion: The concentration of hydrophilic polymers and plasticizers had a significant effect on the formulation and assessment characteristics of thin film. Mannitol assisted in masking the bitter taste of RH.

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Section: Introductionmentioning

confidence: 99%

“…are benefited. Another value-added advantages are pleasant taste, ease of handling, accurate dosing and suitable for all age groups [7,8].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Ramosetron Hydrochloride Mouth Dissolving Thin Film for Enhanced Therapeutic Efficacy and Palatability

GUNDE,

PIMPALE,

GAIKWAD

et al. 2023

Int J App Pharm

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Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation

Attar,

Ghurghure,

Sumit

2024

IJPCA

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Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.

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A Review on Fast-Dissolving Oral Film

Kawale,

Neha B Autade,

Narhare

et al. 2023

Asian J Pharm Clin Res

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Due to their increased comfort and flexibility, fast-dissolving oral films are the most cutting-edge oral solid dose form. It increases the effectiveness of APIs by dissolving in the oral cavity in under a minute after coming into touch with less saliva than fast-dispersing tablets, without chewing, and without the requirement for water for administration. Some patients, especially those who are young or elderly, have trouble chewing or swallowing solid dose forms. The fear of choking prevents many young and geriatric patients from taking these solid preparations. Consequently, orally dissolving pills have been developed. Due to consumer demand for a fast-dissolving product over conventional tablets or capsules, OTFs have gained a position as an alternative in the market. Depending on the film thickness and choice of the polymer matrix, these films can be adjusted to release the medicine more gradually. These films typically disintegrate in seconds to release the active ingredients. When a dosage form is placed on the tongue or in the oral cavity, it can swiftly hydrate, adhere, and dissolve, allowing for rapid local or systemic drug delivery. This type of dosage form is referred to as a film or strip.

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Formulation and Evaluation of Oral Disintegrating Film of Atenolol

Cited by 5 publications

References 7 publications

Development and Evaluation of Ramosetron Hydrochloride Mouth Dissolving Thin Film for Enhanced Therapeutic Efficacy and Palatability

Development and Evaluation of Ramosetron Hydrochloride Mouth Dissolving Thin Film for Enhanced Therapeutic Efficacy and Palatability

Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation

A Review on Fast-Dissolving Oral Film

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