Formulation and evaluation of ornidazole dental implants for periodontitis

Abstract

Dental implant is a pharmaceutical device in the form of strip with very small loading and size of 0.25 sq cm. For site-specific one-time continuous delivery of ornidazole an antimicrobial compound with excellent activity against anaerobic microorganism in the treatment of periodontal disease was prepared by solvent casting technique using ethyl cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose K4M and Eudragit RL-100 with dibutylphthalate as plasticizer. The physicochemical parameters like thickness, weight variation, content uniformity and release characteristics were evaluated The drug release was initially high on day one to achieve immediate therapeutic level of drug in pocket, followed by marked fall in release by day two, and progressive moderate release profile to maintain therapeutic level following anomalous transport mechanism. Formulation V6 released 97.07% of drug at the end of 120 h and was considered as best formulation. In vitro antibacterial activity was carried out on Streptococcus mutans. Preparation of dental implants: Method used for the preparation of dental implants was solvent casting technique 3 using chloroform and dichloromethane (1:1) mixture. A total of six formulations

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“…Thickness uniformity of the films [2] The thickness of each film (size of 1 cm 2 ) was measured using screw gauge at different positions of the film, and the average thickness was calculated.…”

“…The surface pH was measured by means of pH paper on the surface of the swollen film. [2] Percentage moisture loss [4] The percentage moisture loss was determined by keeping the periodontal films in desiccators. The moisture content value was calculated by the equation:…”

“…[1,2] Periodontal disease is a localized inflammatory response due to microbial infection of a periodontal pocket arising from the accumulation of plaque. This produces an inflammatory response in adjacent tissues, and these diseases may be broadly classified according to the extent of periodontal tissue involvement.…”

Formulation development of smart gel periodontal drug delivery system for local delivery of chemotherapeutic agents with application of experimental design

“…At pre-determined time intervals, 1 ml samples of the receptor fluid were taken for 12 h. The medium was replaced after each sampling. Ornidazole concentration in each sample was determined by diluting 1 ml of sample up to 10 ml and analyzed spectrophotometrically at 318 nm (Mastiholimath et al, 2006) using Pharmaspec UV-1700 (UV-Visible Spectrophotometer by Shimadzu, Japan).…”

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“…[11] Hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose K 4 M (HPMC K 4 M), and Eudragit RL-100 copolymers have already been used as excipients of sustained release implant material in dentistry. [12] Cefixime is a third generation broad spectrum cephalosporin. It is used to treat infections of ear, sinuses, throat, chest, and lungs.…”