Formulation and evaluation of periodontal in situ gel

Garala, Kevin; Joshi, Parth; Shah, Malay; Ramkishan, A; Patel, Jay

doi:10.4103/2230-973x.108961

Cited by 142 publications

(95 citation statements)

References 25 publications

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“…However, long-term use of systemic drugs is fraught with potential danger including resistant strains and superimposed infections (Garala et al, 2013). The increasing resistance in many common pathogens to currently used therapeutic agents raised the interest to discover novel anti-infective natural compound derived from plants origin.…”

Section: Introductionmentioning

confidence: 99%

“…In-situ gel-forming formulations is currently a novel idea to deliver drugs as a liquid dosage form, which then form strong gels after application at delivery site, thus prolonging the residence time of the active substance (Garala et al, 2013). Amongst in-situ gelling polymers, thermosensitive systems containing poloxamer have been investigated as a convenient dosage form for application into periodontal pocket.…”

Section: Introductionmentioning

confidence: 99%

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Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

et al. 2017

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This study aimed to develop syringeable in-situ curcumin (cur) gel for the treatment of periodontal pockets as well as to evaluate the clinical efficacy of Cur in-situ gel formulation. Different in-situ gel formulations of Cur were prepared using 30% of pluronic F127, and 1% of carbopol P934. The formulations were evaluated regarding gelation temperature, pH, viscosity, syringeability study, in-vitro release and chemical stability of cur. The effect of aging of gel formulations for 3months in refrigerator was investigated. The selected formulation was clinically evaluated through the determination of probing depth, plaque index, and bleeding index at baseline and 1 month after application. The formulations showed accepted gelation temperature ranging from 28 to 34 C and all had pH value of 4. The viscosity of the formulations at 4 C ranged from 19 000 to 37 000 cP. All formulations were easily syringeable through 21 gauge needle at cold temperature. Curcumin stability during the release study was maintained. Aging showed no significant effect on release profile, drug content, or the pH after 3 months, while it showed a slight increase in viscosity with concomitant decrease in gelation temperature. Selected formulations delivered into periodontal pocket evaluated clinically showed to be effective. The treated group revealed that the adjunctive use of intracrevicular 2% curcumin in-situ gel adjunct to mechanical treatment in patients with adult periodontitis could aid in significant clinical reduction of probing depth, bleeding index, and to less extent of plaque. This indicates that curcumin in this novel drug delivery system is an excellent candidate for periodontal disease treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

et al. 2017

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“…With the increase in concentration of PF68, micelle formation appears followed by micellar aggregation [28]. Considering the 9 problem of micelle formation and aggregation, 0.5% PF68 was selected for PLGA NP treatment and used for further analysis in this study.…”

Section: Discussionmentioning

confidence: 99%

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Shubhra

Tóth

Gyenis

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Lifetime prolongation for hydrophobic drug carriers has been the focus of interest for many years. Poloxamer (Pluronic F68, PF68) has been employed in this study for modifying the surface of magnetic poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with human serum albumin (HSA) model drug. Surface characteristics of untreated and PF68 treated NPs were analyzed by size, zeta potential and electrophoretic mobility studies. UV/VIS spectroscopic analysis, isothermal titration calorimetry (ITC) and dynamic light scattering methods were used to investigate serum protein (bovine serum albumin, BSA) adsorption. Results showed the successful surface attachment of PF68. Among different concentrations (0.1 to 1% wt/vol) of PF68 studied, 0.5% was found to be the most useful, since a higher concentration can issue in micelle formation. 50% less BSA tended to be adsorbed on the treated NPs in comparison to the untreated ones.

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“…[13] Hence, the aim of the present work is to develop injectable in situ gelling system of antihypertensive drug Diltiazem HCl by using biopolymer to have a controlled kinetic drug release. Preparation of injectable in situ gels [14] Injectable in situ gel was prepared by cold method. …”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Formulation and Evaluation of Injectable in Situ Gelling Matrix System of Diltiazem Hydrochloride for Controlled Drug Release

Sanjana¹

2017

WJPPS

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The aim of the present work was to formulate and evaluation injectable in situ gel matrix containing Diltiazem hydrochloride by cold method.Diltiazem hydrochloride is an anti-hypertensive agent it is rapidly and almost completely absorbed from the gastro intestinal tract but undergoes extensive first-pass hepatic metabolism. Thus oral bioavailability is only 40%. The main objective of present study is to increase the bioavailability; reducing the dose. This formulation was prepared by using thermosensitive polymer Pluronic F 127 (20%) together with carbopol 934P and HPMC. The drug polymer compatibility was studied by FTIR. The formulations were evaluated for clarity, sterility, gelation temperature, gelation time, viscosity, Syringeability, drug content and drug release. The non-irritant nature of the developed formulation was confirmed by the HET-CAM test. In vivo appearance studies were conducted on dead goat ear. The optimized formulation F6 had viscosity suitable for injecting, formulation F6 showed controlled drug release and it was found to be 80.97% up to 12 hrs. The stability studies performed on F6 showed no single change in physical appearance and drug release. It was concluded that the drug release performance was greatly affected by the polymer used in the preparation of injectable in situ gel.KEYWORDS: injectable in situ gel, Diltiazem hydrochloride, Pluronic F 127, preparation of in situ gel, evaluation of in situ gel, stability studies.

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Formulation and evaluation of periodontal in situ gel

Cited by 142 publications

References 25 publications

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Formulation and Evaluation of Injectable in Situ Gelling Matrix System of Diltiazem Hydrochloride for Controlled Drug Release

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