Formulation and Evaluation of Piroxicam Fast Dissolving Tablets Using Direct Compression and Sublimation Method

Kumar, Inder; Chaudhary, Dipima; Thakur, Bhumika; Pandit, Vinay

doi:10.22270/jddt.v10i3-s.4063

Cited by 5 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tablets have been made via direct compression and the disintegration time of all batches produced was checked and the greatest polymer concentration required to achieve a shorter disintegration time was determined [17].…”

Section: Procedures For Preparation Of Mouth-dissolving Tabletmentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

View full text Add to dashboard Cite

Objective: The present work is aim to design, development and fabrication of mouth dissolving tablets containing extract of Tribulus terrestris for the treatment of hypertension. Methods: The extract of fruits of Tribulus terrestris was formulated as mouth dissolving tablets (MDTs) by full factorial design at 32 levels and prepared by direct compression method using super integrants like sodium starch glycolate and cross povidone. Furthermore, the tablet was evaluated for thickness, hardness, weight variation, wetting time, disintegration time, and in vitro drug release study. Results: The tablets were analyzed for a variety of characteristics, such as hardness (2.4-2.9 kg/cm2), friability (0.33-1.7%), disintegration time (20-34 s), drug content (95.32-99.09%), water uptake ratio (26-48%), wetting time (29-69 s), and in vitro drug release illustrated in 5 min (99.04-68.21%). There was no interaction between both the drug and the polymer, according to FTIR and DSC studies. Conclusion: The research revealed that Tribulus terrestris fruits extract can be designed, developed and fabricated into mouth dissolving tablet for the treatment of hypertension with improved bioavailability and expected patient compliance.

show abstract

Section: Procedures For Preparation Of Mouth-dissolving Tabletmentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The investigation was conducted with DSC Q1000 TA equipment. Approximately 2-5 mg of sample was put in standard aluminum pans and scanned from 5 °C to above its melting point at a rate of 10 °C/min with dry nitrogen (flow rate 50 ml/min) as the effluent gas [26].…”

Section: Differential Scanning Calorimetry (Dsc) Studiesmentioning

confidence: 99%

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

et al. 2023

View full text Add to dashboard Cite

Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a concentration of Crospovidone 30 mg, shows 91.30% drug release respectively at the end of 12 min. Conclusion: The mouth-dissolving tablets of ambrisentan were successfully designed, developed, and fabricated. It can be reasonably concluded that the AS6 batch of mouth-dissolving tablets of ambrisentan with 30 mg of crospovidone exhibited maximum cumulative drug release in 12 min.

show abstract

“…Various formulations have been developed for PXM like fast dissolving tablets (7), transferosme gel (6), microsponge tablet (5), solid self-micro emulsifying dispersible tablets (8), and dispersible tablets (9) to improve its solubility property. No one developed PXM liquid fills for soft gels.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Piroxicam Liquid Fill Formulations

Maddela,

Manjula,

Reddy

et al. 2024

Curr. Trends Biotechnol. Pharm.

View full text Add to dashboard Cite

The present investigation includes the preparation and evaluation of liquid filling formulations of Piroxicam (PXM), a non-steroidal anti-inflammatory drug, to improve its dissolution properties. Liquid fills were prepared using various excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), and methanol as co-solvents, poly vinyl pyrrolidone (PVP K-30) as solubilizing agent, and hydroxyl propyl methyl cellulose as gelling agent. The prepared PXM liquid fills were evaluated for appearance, recrystallization, viscosity, clarity, assay and in vitro drug release studies. The compatibility of PXM and excipients in liquid fills was confirmed by FTIR. DSC studies together with XRD confirmed the absence of PXM recrystallization within the liquid fills. The viscosity of the prepared liquid fills was found to be in the range of 60.9-591.7 cps. Liquid fills containing PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and complete PXM release was observed within 60 min for all PXM liquid fills and the PXM release from liquid fills followed diffusion mechanism. The liquid fills showed 98-102% PXM content even after 6months time period indicating that the PXM was stable in liquid fill formulations.

show abstract

Formulation and Evaluation of Piroxicam Fast Dissolving Tablets Using Direct Compression and Sublimation Method

Cited by 5 publications

References 6 publications

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

Formulation and Evaluation of Piroxicam Liquid Fill Formulations

Contact Info

Product

Resources

About