Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention

Kharia, Ankit Anand; Singhai, Akhlesh Kumar; Verma, Richa

doi:10.37285/ijpsn.2011.4.4.6

Cited by 21 publications

(10 citation statements)

References 18 publications

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“…According to the research conducted by Kharia et al . the zeta-potential value more than ǀ30 mV rendered the system more stable because the repulsive force between particles prevented aggregation ( 27 ). The SK32-UA10 formula indicated a zeta-potential value less than -30 mV (-41.99 mV) leading to the conclusion that the niosomes were stable because there was considerable electrostatic stabilization ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer

Miatmoko

Safitri

Aquila

et al. 2021

Research in Pharmaceutical Sciences

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Background and purpose: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. In this study, we evaluated the effect of different ratios of Span ® 60-cholesterol-UA and also chitosan addition on physical characteristics and stability of niosomes to improve oral biodistribution. Experimental approach: UA niosomes (Nio-UA) were composed of Span ® 60-cholesterol-UA at different molar ratios and prepared by using thin layer hydration method, and then chitosan solution was added into the Nio-UA to prepare Nio-CS-UA. Findings/Results: The results showed that increasing the UA amount increased the particle size of Nio-UA. However, the higher the UA amount added to niosomes, the lower the encapsulation efficiency. The highest physical stability was achieved by preparing niosomes at a molar ratio of 3:2:10 for Span ® 60, cholesterol, and UA, respectively, with a zeta-potential value of -41.99 mV. The addition of chitosan increased the particle size from 255 nm to 439 nm, as well as the zeta-potential value which increased from -46 mV to -21 mV. Moreover, Nio-UA-CS had relatively higher drug release in PBS pH 6.8 and 7.4 than Nio-UA. In the in vivo study, the addition of chitosan produced higher intensities of coumarin-6-labeled Nio-UA-CS in the liver than Nio-UA. Conclusion and implications: It can be concluded that the ratio of Span ® 60-cholesterol-UA highly affected niosomes physical properties. Moreover, the addition of chitosan improved the stability and drug release as well as oral biodistribution of Nio-UA.

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Section: Discussionmentioning

confidence: 99%

Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer

Miatmoko

Safitri

Aquila

et al. 2021

Research in Pharmaceutical Sciences

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“…A particle with a size higher than 100 nm is proven to enter the cells through endocytosis or pinocytosis [30]. Furthermore, the pI values of the complex that fall in the range between 0.01 to 0.7 showed that this particle behaved as a monodispersed system, while the higher value of pI than 0.7 would indicate larger particle size distribution in the solution [31]. Another physiochemical character observed was zeta potential that shows the charged of the complex.…”

Section: Discussionmentioning

confidence: 99%

Potential of Nanoparticles Chitosan for Delivery pcDNA3.1-tat

et al. 2021

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The development of Jembrana disease vaccine is importance to prevent the loss of Bali cattle industry in Indonesia. This study aims to prepare a Jembrana DNA vaccine. The data Tat protein sequences gained from NCBI and the consensus process has been finished by the MultAlign program, and then Cloning of the pcDNA3.1-tat has been successfully performed on E. coli DH5α and confirmed by PCR, restriction analysis and sequencing. The propagated plasmids were prepared as DNA-chitosan complex and physiochemical characterized using Particle Size Analyzer. Complex with a 1:2 (wt/wt) ratio of DNA and chitosan have a mean diameter of 268.5 nm and zeta potential +25.1 mV and the value of Cytotoxicity Assay 80-90% as compared to the untreated cells that used as negative control, so it can be concluded that nanoparticles chitosan has good potential as a carrier agent for pcDNA3.1-tat.

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“…The parameters i.e. "optical checking, smoothness, color, transparency and flexibility" were observed [10].…”

Section: Characterization Of Trandolapril Containing Transdermal Film...mentioning

confidence: 99%

Development and Designing Trandolapril Topical Film for Management of Cardiac Stroke

Maruti¹,

Shirsat²

2022

JASR

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Transdermal drug delivery system (TDDs) is novel specified dosage forms, when drug deliver through the skin at controlled rate to the systemic circulation as applied to the intact skin. The present investigation is to prepared transdermal films of trandolapril intended for controlled release polymeric transdermal patch for a care of cardiac patients. The objective of current work is to develop the polymeric transdermal patch for immediate release of drug materials. The transdermal film of trandolapril was prepared by using various combinations of the polymers with solvent evaporation technique. The proposed formulations have a number of variables i.e. plasticizers, penetration enhancers, rate controlling process and adhesion on skin. We may apply biologically active permeation enhancers i.e. Isopropyl myristate, Propylene glycol and Mineral oils etc. The result concluded that polymers chitosan have hydrophilic nature and able to enhance spreadability and dispersibility of the water soluble trandolapril enhanced drug release more than 95.5% within a 6 - 7 h as needed for immediate release. The all evaluation parameters and in-vitro drug release study was used for selection of best polymeric film prepared with chitosan (2%) and PVP (1%) as plasticizer for the preparation of single layered transdermal film as first immediate release layer.

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Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention

Cited by 21 publications

References 18 publications

Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer

Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer

Potential of Nanoparticles Chitosan for Delivery pcDNA3.1-tat

Development and Designing Trandolapril Topical Film for Management of Cardiac Stroke

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