Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies

Ghumman, Shazia Akram; Mahmood, Arshad; Noreen, Sobia; Rana, Mavra; Hameed, Huma; Ijaz, Bushra; Hasan, Sara; Aslam, Afeefa; Rehman, Muhammad Fayyaz ur

doi:10.1016/j.arabjc.2022.103811

Cited by 30 publications

(20 citation statements)

References 48 publications

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“…However, at an alkaline pH, there was more swelling, followed by degradation and breakdown. Moreover, the swelling of QSM‐alginate‐cefixime microspheres can be explained by the ion exchange in the basic buffer 31 . In addition, because of the increasing concentration of hydroxyl ions (OH − ), the complexation between the –COO − and metal ions could be weakened 32 .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the swelling of QSM-alginate-cefixime microspheres can be explained by the ion exchange in the basic buffer. 31 In addition, because of the increasing concentration of hydroxyl ions (OH − ), the complexation between the -COO − and metal ions could be weakened. 32 Moreover, bentonite contains hydroxyl groups, which can form hydrogen bonds with alginate and effectively inhibit further swelling of the granules.…”

Section: Behaviour Of Granules In Watermentioning

confidence: 99%

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Controlled‐release alginate‐bentonite polymer gel granules of emamectin benzoate and control efficacy against Spodoptera frugiperda

Zhu

Zhang

Chen

et al. 2022

Pest Management Science

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Background: The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith), is known to cause large agricultural production losses. Emamectin benzoate is one of the most effective insecticides to control this pest; however, its effective time is not sufficiently long to control FAW. Therefore, it is important that new controlled insecticide formulations with new application methods are developed.Results: A series of emamectin benzoate polymer gel granules were prepared with sizes ranging from 0.95 to 1.5 mm. As the bentonite content increased, the release rate decreased. The cumulative release process of emamectin benzoate mainly depends on the cracks in the surface of the granules, and the release rate can be described by non-Fickian and Fickian diffusion, which are closely related to the water content. By spreading the developed polymer gel granules into maize leaf whorls, the control effect reached 83% after 21 days in field trials.Conclusion: A novel polymer gel granule was developed that can effectively regulate emamectin benzoate release. By broadcasting polymer gel granules into maize leaf whorls, significant control efficacy against FAW can be obtained, and this could potentially be used for the effective control of FAW.

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Section: Resultsmentioning

confidence: 99%

Section: Behaviour Of Granules In Watermentioning

confidence: 99%

Controlled‐release alginate‐bentonite polymer gel granules of emamectin benzoate and control efficacy against Spodoptera frugiperda

Zhu

Zhang

Chen

et al. 2022

Pest Management Science

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“…Similarly, the individual spectra of Na-Alg, COM, and MFH were taken to determine the interaction between the drug and excipient polymers. 17 2.10.4. Investigation of the In Vitro Drug Release and Kinetic Mechanism.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…Previously, COM/Na-Alg-based beads have been used for sustained transport of cefixime-HCl. 17 Metformin HCl (MFH) is a chemically derived biguanide anti-hyperglycemic drug, frequently used in the management of diabetes mellitus type II. A frequent high (1.5−3 g/day) dose is usually administered due to its poor pharmacokinetics such as a low bioavailability of 50−60%, a short half-life of 3−4 h, and ≤5 protein binding, which lead to side effects (lactic acidosis and GIT irritation).…”

Section: Introductionmentioning

confidence: 99%

Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

et al. 2023

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In recent years, attention has shifted toward the utilization of natural polymers for encapsulation and sustained release of health-hazardous drugs. The purpose of this work is to define and assess the sustained delivery potential and mucoadhesive potential of a Cydonia oblonga mucilage (COM) and sodium alginate (Na-Alg)-constituting polymeric delivery carrier of antidiabetic drugs with a specific end goal to retain metformin HCl in the stomach while expanding the drug’s bioavailability. Metformin HCl was encapsulated in mucoadhesive microspheres by an ionic gelation method. Polymers with different combinations were tried, and the resulting mucoadhesive COM/Na-Alg microspheres were assessed for particle size (mm) PS/Y1, drug encapsulation efficiency DEE (%)/Y2, and in vitro percentage cumulative drug release R12h/Y3 using Drug Design Expert software version 10. The response surface methodology by a 32-central composite design predicted optimal synthesis parameters for the microspheres to be 295 mg for COM and 219 mg for Na-Alg. An optimized formulation was prepared under these conditions and used to evaluate the micrometric properties, morphology and structural characteristics, swelling behavior, in vitro drug release, and kinetics. Acute toxicity studies were carried out on blank COM/Na-Alg microspheres to deem them safe for in vivo studies. The DEE (%) was calculated to be 85.8 ± 1.67, whereas scanning electron microscopy (SEM) showed a coarse surface with characteristic wrinkles and cracks with an optical microscopic particle size of 0.96 ± 2.45. The ex vivo tests showed great mucoadhesive properties and good swelling behavior with pH-responsive drug release and a significant reduction in in vivo blood glucose levels. The results advocated the use of optimized microspheres to enhance the bioactivity with a possible dose reduction, making it less symptomatic, reducing the expense of the treatment, and subsequently facilitating better patient compliance.

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“…Aqueous solubility is an important parameter to get the desired drug concentration in systemic circulation for the pharmacological response. A low aqueous solubility leads to a slow dissolution process that limits a drug’s absorption from the gastrointestinal tract. − Therefore, to enhance the bioavailability of a drug, its solubility in water should be enhanced. , …”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical and Pharmacological Evaluation of Amoxicillin after Solubility Enhancement Using the Spray Drying Technique

et al. 2022

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The dose frequency of drugs belonging to class II is usually high and associated with harmful effects on the body. The study aimed to enhance the solubility of the poorly water-soluble drug amoxicillin (AM) by the solid dispersion (SD) technique. Six different SDs of AM, F1−F6, were prepared by the spray drying technique using two other carriers, HP-β-CD (F1−F3) and HPMC (F4−F6), in 1:1, 1:2, and 1:3 drug-to-polymer ratios. These SDs were analyzed to determine their practical yield, drug content, and aqueous solubility using analytical techniques such as Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and powder X-ray diffraction. The effect of polymer concentration on SDs was determined using aqueous solubility, in vitro dissolution, and in vivo studies. The results showed no drug−polymer interactions in SDs. Solubility studies showed that SDs based on the drug-to-polymer ratio of 1:2 (F2 and F5) were highly soluble in water compared to those with ratios of 1:1 and 1:3. In vitro dissolution studies also showed that SDs with a ratio of 1:2 released the highest drug concentration from both polymeric systems. The SDs based on HPMC confirmed the more sustained release of the drug as compared to that of HP-β-CD. All the SDs were observed as stable and amorphous, with a smooth spherical surface. In vivo studies reveal the enhancement of pharmacokinetics parameters as compared to standard AM. Hence, it is confirmed that spray drying is an excellent technique to enhance the solubility of AM in an aqueous medium. This may contribute to the enhancement of the pharmacokinetic behaviors of SDs.

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Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies

Cited by 30 publications

References 48 publications

Controlled‐release alginate‐bentonite polymer gel granules of emamectin benzoate and control efficacy against Spodoptera frugiperda

Controlled‐release alginate‐bentonite polymer gel granules of emamectin benzoate and control efficacy against Spodoptera frugiperda

Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

Pharmaceutical and Pharmacological Evaluation of Amoxicillin after Solubility Enhancement Using the Spray Drying Technique

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