Formulation and Evaluation of Sustained Release Tablets of Tramadol

Abstract

The main aim of the proposed work was to develop Tramadol matrix tablets, sustained release dosage form. Tramadol is a narcotic analgesic proposed for moderate to severe pain Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release tablets were prepared by direct compression method using Hydroxypropyl methyl cellulose as a K100M grade, Karayagum and Guar gum in varying ratios. Tablets blends were evaluated for Bulk density, Tapped density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these

Role of chromatographic methods in quantitative assessment of Aceclofenac: A brief review

“…Due to short half life, it is necessary to be administered frequently in order to maintain the desired concentration . Therefore, to single dosage forms (Shivhare et al, 2009). AC should not be administered to patients with peptic ulcers or GI bleeding, moderate or severe renal impairment, sensitivity to aceclofenac or other NSAIDs.…”