Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using &lt;i&gt;Brachystegia eurycoma &lt;/i&gt;gum

Okafo, Sinodukoo Eziuzo; Avbunudiogba, John A.; Ejomafuvwe, Ejiro

doi:10.4314/jpb.v17i1.7

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…Other peoples in Nigeria such as the Yoruba, the Ijaw, the Edo call it akalado or eku, akpakpa or apaupan and okwen respectively. BEG compares creditably with gums used commercially in the food industry [9]. BEG has a pH of 5.5 at 28ºC.…”

Section: Introductionmentioning

confidence: 92%

“…The procedure of Okafo et al [9,12] was used. The fresh seeds of Brachystgsia eurycoma were bought from Abraka Main Market, Abraka, Delta State, Nigeria.…”

Section: Extration Of Brachystegia Eurycoma Gummentioning

confidence: 99%

“…The cloudy dispersion (mucilage) formed due to the dispersion of BEG in hot water could be used as a binder or suspending agent. BEG has been used as suspending agent in metronidazole suspensions [11], as a hydrophilic polymer matrix for sustained released diclofenac [9] and as a swellable polymer for gastro retentive metronidazole tablets [12]. BEG was co-processed with an egg albumen mixture and used to formulate sustained-release metronidazole tablets [13].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of physicochemical, in vivo analgesic and antiinflammatory activities of Brachystegia eurycoma gum-based naproxen loaded niosomal gels

Okafo

Ordu

Ofagbor

et al. 2023

German J. Pharm. Biomaterials

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Protracted oral Naproxen administration for acute and chronic conditions, such as rheumatoid arthritis treatment, may cause peptic ulcers. The topical application of Naproxen will circumvent this effect. This research aims to assess the physicochemical, anti-inflammatory and analgesic properties of Naproxen-loaded niosomal gels formulated using Brachystegia eurycoma gum (BEG) as the gelling polymer. BEG was isolated by acetone precipitation of filtrate produced by cold maceration of Brachystegia eurycoma seeds powder. Naproxen and BEG compatibility was evaluated using Fourier transform infrared FTIR) spectroscopy. Naproxen-loaded niosomes were produced with cholesterol, surfactant (tween 80) and water using a modified ethanol injection method. The formulated niosomes were incorporated into either BEG (5, 7.5 or 10%) or HPMC (1.5, 5%) gel base to produce the respective Naproxen-loaded niosomal gels. The niosomal gels were assessed for their physicochemical, antiinflammatory and analgesic properties using a commercially available gel as a positive control. There was no incompatibility between BEG and Naproxen. The formulated gels' pH ranged from 6.4 to 7.3, while the viscosity ranged from 1476.2 to 2980 mPas. The formulated gels had good extrudability and spreadability compared to the commercially available gel (1%). In-vivo studies using white albino rats showed that gels from the optimized formulation (F1) had comparable anti-inflammatory (26.5% inhibition) and analgesic properties to the commercially available gel (31.3% inhibition). Naproxen-loaded niosomal gels having good physicochemical, analgesic and anti-inflammatory properties were successfully formulated using BEG as a gelling agent.

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Section: Introductionmentioning

confidence: 92%

“…The procedure of Okafo et al [9,12] was used. The fresh seeds of Brachystgsia eurycoma were bought from Abraka Main Market, Abraka, Delta State, Nigeria.…”

Section: Extration Of Brachystegia Eurycoma Gummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of physicochemical, in vivo analgesic and antiinflammatory activities of Brachystegia eurycoma gum-based naproxen loaded niosomal gels

Okafo

Ordu

Ofagbor

et al. 2023

German J. Pharm. Biomaterials

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“…This procedure was repeated for formulations M2 and M3. 24 The angle of repose was calculated using equation 5.…”

Section: Angle Of Reposementioning

confidence: 99%

Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant

Okafo,

Monioro,

Enyaosah

et al. 2023

J. Drug Delivery Ther.

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This research was done to formulate and assess the sustained release property of metformin tablets prepared from metformin microcapsules produced by ionic gelation technique using Sida acuta gum or sodium carboxymethylcellulose as release retardant. Sida acuta gum was produced by isopropyl alcohol precipitation of the filtrate obtained from distilled water maceration of powdered dried Sida acuta leaves. Metformin and Sida acuta gum compatibility was determined using FTIR. Metformin microcapsules were prepared by ionic gelation technique using sodium alginate alone or with either Sida acuta gum or sodium carboxymethylcellulose as release retardant. The microcapsules were evaluated for % yield and flow properties. The size and surface morphology of the microcapsules were determined using scanning electron microscopy. Metformin tablets were prepared from the microcapsules using direct compression technique. The tablets were evaluated for hardness, friability and in vitro dissolution. There was no major incompatibility between metformin and Sida acuta gum. The microcapsules have excellent flow property and were of micrometer size range. They have rough surfaces. The friability of the tablets ranged from 0.4-1.6% while the hardness was from 3.82-11.17 Kgf. The tablets from formulations M2 failed both friability and hardness test. About 44.5-47.1% of metformin was released from the tablet formulations after 6 h while 86.0-100% was released after 10 h. All the tablet formulations showed sustained release ability. Keywords: Microcapsules, metformin, Sida acuta gum, sustained release, ionic gelation

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Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris

Rupali¹,

Malviya

2021

DDL

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Background: The chronotherapy concept attains considerable focus towards itself due to its pulsatile fashion rather than continuous delivery. The delivery of the right amount of drug to the target organ at the most appropriate time is fulfilled by using the chronotherapeutic dosage form. Aim: The present study aims to develop and evaluate a chronotherapeutic drug delivery system by using natural polymer for time specific drug delivery at the target site. Material and Method: Tamarind seed polysaccharide was extracted and used in the preparation of core tablets. Nine formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on 6 mm punch. The core tablets were prepared by using the compression coating method. The three batches F1, F2 and F3 were prepared by using tamarind gum in different concentration i.e. 45%, 22.5% and 67.5% respectively and compressed at 8 tonnes of pressure on 12 mm of punch. The finally compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl alcohol used as a solvent. In a controlled medium, a stability study was performed to evaluate the physical appearance, drug content and release of the prepared core tablet. Result: All the nine formulations of tablets were prepared successfully and the evaluation studies (thickness, weight variation, hardness, friability etc.) revealed that all the formulations were within the official range. The release study of the drug revealed that the formulation F7 containing 67.5% of tamarind polymer, coated with 2%, 4% and 5% of ethyl cellulose solution released 59.68±1.03% (Q50%) drug within 5 h whereas, 87.09±2.08% (Q80%) within 6 h and within 12 h 97.74±2.19% of the drug was released. The formulation F7 was found to be more effective as it released the maximum amount of drug in a short period as compared with other formulations. Conclusion: The coating of core tablets allowed to prepare pharmaceutical dosage form for time specific drug delivery. These chronotherapeutic core tablets can be used for the treatment of angina pectoris and hypertension etc.

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Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using <i>Brachystegia eurycoma </i>gum

Cited by 3 publications

References 13 publications

Evaluation of physicochemical, in vivo analgesic and antiinflammatory activities of Brachystegia eurycoma gum-based naproxen loaded niosomal gels

Evaluation of physicochemical, in vivo analgesic and antiinflammatory activities of Brachystegia eurycoma gum-based naproxen loaded niosomal gels

Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant

Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris

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