Formulation and evaluation of thermosensitive flurbiprofen <i>in situ</i> nano gel for the ocular delivery

Maddiboyina, Balaji; Jhawat, Vikas; Desu, Prasanna Kumar; Nakkala, Ramya Krishna; Singh, Sima

doi:10.1080/09205063.2021.1927460

Cited by 26 publications

(12 citation statements)

References 27 publications

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“…TISG has solution-gel transition property, which rapidly transforms into gel state and adheres to the drug site with temperature change, can be administered in various ways, including luminal administration ( Permana et al, 2021 ), mucosal administration ( Maddiboyina et al, 2021 ), transdermal administration ( Khan et al, 2019 ), and subcutaneous injection ( Yu et al, 2017 ). Kangfuxin liquid (KFX) is a patented Chinese medicine of PA, which have been used for UC treatment orally or rectally ( Ma et al, 2018 ; Xue NN et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Tang

Chen

et al. 2023

Front. Pharmacol.

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Objective: The aim of this study was to develop a thermosensitive in situ gel (TISG) as an effective rectal delivery platform for delivering Periplaneta americana extracts (PA) to alleviate ulcerative colitis (UC) and explore the underlying molecular mechanism.Materials and methods: Thermosensitive (poloxamer 407) and adhesive polymers (chondroitin sulfate modified carboxymethyl chitosan, CCMTS) were used to construct the in situ gel. CCMTS and aldehyde poloxamer 407 (P407-CHO) were synthesized and chemically cross-linked by Schiff base reaction to formulate thermosensitive in situ gel, which carried Periplaneta americana extracts (PA/CCMTS-P). The cytotoxicity and cellular uptake of CCMTS-P were investigated in lipopolysaccharide (LPS) -induced macrophages by CCK-8 assay. The anti-inflammatory effects of PA/CCMTS-P were studied in lipopolysaccharide-induced RAW264.7 cells and dextran sulfate sodium (DSS)-induced ulcerative colitis mouse models. In addition, the ability of PA/CCMTS-P to restore the intestinal mucosal barrier after rectal administration was evaluated by immunohistochemical analysis (IHC).Results: PA/CCMTS-P was prepared and characterized as gel with a phase-transition temperature of 32.9°C. The results of the in vitro experiments indicated that the hydrogels promoted the cellular uptake of Periplaneta americana extracts without causing any toxicity as compared to the free gel. PA/CCMTS-P showed superior anti-inflammatory activity both in vitro and in vivo, which restored the damaged intestinal mucosal barrier associated by inhibiting necroptosis in dextran sulfate sodium-induced ulcerative colitis models.Conclusion: The findings from our study show that the rectal administration of PA/CCMTS-P holds a promising potential for the treatment of ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Tang

Chen

et al. 2023

Front. Pharmacol.

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“…The weight of the coated fibre was taken and the amount of drug(s) coated on it was expected on a weight basis. [11] The drug(s) loading was also untiring spectrophotometrically at 319 and 273.8 nm. Coating was done five times and each time, the satisfied of drug(s) extant in the coating was feasible.…”

Section: ) Using Dilute Solution Of Drug(s) (Methods A)mentioning

confidence: 99%

Formulation development and evaluation of site specific periodontal fibers of metronidazole and minocycline hcl

Kumar

Sasidhar

Deepthi

2021

Int. J. Pharm. Sci. Drug Res.

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Periodontal disease is a collective term for a variety of pathological conditions characterized by relapse and inflammation of the gums, periodontal sinews, alveolar bone, and dental cementum. It is a confined inflammatory reaction caused by bacterial infection of a periodontal pocket in conjunction with subgingival plaque. Even though bacteria are the primary cause of periodontal disease, the presence of microbial pathogenic aspects may not be required to cause periodontitis. Periodontal pathogens produce harmful byproducts and enzymes that disrupt extracellular matrices as well as host cell membranes in order to produce nutrients for their growth. A number of antimicrobial products are summarized, as well as the composition of the delivery systems, their use, clinical results, and release. The goal of using an intrapocket device for antimicrobial agent delivery is to achieve and maintain therapeutic drug concentration for the desired period of time. With precise control of the rate at which a specific drug dosage is released from a delivery system without the need for frequent administration, novel controlled drug delivery systems are capable of improving patient compliance as well as therapeutic efficacy. Because of their low cost, greater stability, non-toxicity, biocompatibility, non-immunogenicity, and biodegradability, these are considered superior drug delivery systems. In this study, a site-specific periodontal drug delivery system for Metronidazole and Minocycline HCl was developed. The augmented fibre formulation G-II laterally with scaling and root planning was effective in eliminating local irritants, reducing gingival inflammation, reducing pocket depth, and increasing clinical addition. Method (A) revealed a determined drug release of 81.8 percent over a period of 120 hours, while method (B) released 84 percent drug(s) over a period of 264 hours. For the optimized formulation, the value of n is assumed to be 0.9314 and follows zero-order. It also measured the restricted infection and prevented the formation of new lesions. In the current revision, there was a significant decrease in mean plaque index, gingival index, sulcus bleeding index, and probing pocket depth, as well as a significant increase in clinical affection. The current study’s local drug delivery system is artless and simple to use.

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“…Poloxamers or Pluronics © -nonionic triblock copolymers composed of a central hydrophobic chain of poly(propylene oxide) flanked by two hydrophilic chains of poly(ethylene oxide)-represent one class of thermosensitive gels. These polymers and their combinations with other polymers have been extensively investigated for ocular drug delivery [177][178][179][180]. Thus, the combination of cationic nanostructured lipid carriers and thermosensitive Poloxamer 188 gel allowed to increase the bioavailability of curcumin by improving corneal permeation and retention capacity from 1.5 up to 5 h in the aqueous humor of rabbits [181].…”

Section: In Situ Hydrogels As An Additional Carrier Of Drug-loaded Nanoparticlesmentioning

confidence: 99%

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

Vaneev

Tikhomirova

Чеснокова

et al. 2021

IJMS

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Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among these, nanosize carriers are the most attractive. The review is focused on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles and nanomicelles. Studies in vitro and in vivo have demonstrated that new formulations could help to improve the bioavailability of the drugs, provide sustained drug release, enhance and prolong their therapeutic action. Promising results were obtained with drug-loaded nanoparticles included in in situ gel.

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Formulation and evaluation of thermosensitive flurbiprofen in situ nano gel for the ocular delivery

Cited by 26 publications

References 27 publications

Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Formulation development and evaluation of site specific periodontal fibers of metronidazole and minocycline hcl

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

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