Formulation and evaluation of transdermal nanogel for delivery of artemether

Nnamani, Petra O.; Ugwu, Agatha; Nnadi, Ogechukwu H; Kenechukwu, Franklin Chimaobi; Ofokansi, KC; Attama, Anthony A.; Lehr, Claus‐Michael

doi:10.1007/s13346-021-00951-4

Cited by 32 publications

(26 citation statements)

References 48 publications

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“…Artemether is currently available in oral and injectable dosage forms. Nnamani et al (2021) successfully formulated and characterized nanogels for trans-dermal administration of lower-dose artemether. The formulated nanogel proved that artemether can be administered through the skin.…”

Section: Nanogels For Cancer Therapymentioning

confidence: 99%

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

et al. 2022

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Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level of human development. Globally, it was estimated that there were 19.3 million new cases of cancer and almost 10 million deaths from cancer in 2020. The importance of prevention, early detection as well as effective cancer therapies cannot be over-emphasized. One of the important strategies in cancer therapy is targeted drug delivery to the specific tumor sites. Nanogels are among the several drug delivery systems (DDS) being explored as potential candidates for targeted drug delivery in cancer therapy. Nanogels, which are new generation, versatile DDS with the possession of dual characteristics of hydrogels and nanoparticles have shown great potential as targeted DDS in cancer therapy. Nanogels are hydrogels with a three-dimensional (3D) tunable porous structure and a particle size in the nanometre range, from 20 to 200 nm. They have been visualized as ideal DDS with enormous drug loading capacity, and high stability. Nanogels can be modified to achieve active targeting and enhance drug accumulation in disease sites. They can be designed to be stimulus-responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. Drugs with severe adverse effects, short circulation half-life, and easy degradability by enzymes, such as anti-cancer drugs, and proteins, are suitable for delivery by chemically cross-linked or physically assembled nanogel systems. This systematic review summarizes the evolution of nanogels for targeted drug delivery for cancer therapy over the last decade. On-going clinical trials and recent applications of nanogels as targeted DDS for cancer therapy will be discussed in detail. The review will be concluded with discussions on safety and regulatory considerations as well as future research prospects of nanogel-targeted drug delivery for cancer therapy.

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Section: Nanogels For Cancer Therapymentioning

confidence: 99%

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

et al. 2022

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“…Ex vivo skin permeation tests revealed that a considerable amount of artemether passed through the skin of the rat's abdomen. A two-patch per week concurrent application of the studied nanogels could provide a 100% cure of malaria using a lower dose of artemether (50 mg) to reduce severe side effects [56].…”

Section: Application Of Nlcs In Transdermal Drug Deliverymentioning

confidence: 99%

Nanostructured Lipid Carriers for Transdermal Drug Delivery

et al. 2022

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Transdermal drug delivery offers many advantages over oral delivery, such as avoiding first-pass metabolism, enhancing the bioavailability of poorly soluble drugs, and providing better patient compliance. However, only small lipophilic molecules can be delivered across the stratum corneum, the outermost layer of the skin. Unfortunately, the delivery of larger molecules remains a challenge. Nanostructured lipid carriers (NLCs) are second-generation lipid nanocarriers composed of biocompatible solid lipids, liquid lipids, surfactants, and co-surfactants. NLCs can be loaded with various classes of drugs, provide a controlled drug release profile, enhance drug stability, and be scaled up without needing organic solvents. This review article discusses the features, composition, formulation processes, and characterization of NLCs and their potential use in transdermal drug delivery.

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“…Therefore, most of the created transdermal formulations are made in the form of gels, which facilitates the application of these compositions and makes it possible to compare them with commercially available gels and creams. Carbopol 934 [184], hydroxypropyl methylcellulose [185], or even mixtures of Carbopol 971P, Poloxamer 407, and Prosopis Africana peel powder are most commonly used for this purpose [186]. In [179] sodium carboxymethyl cellulose was chosen to increase the viscosity of transfersomes solution.…”

Section: Transfersomes and Transethosomesmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

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Formulation and evaluation of transdermal nanogel for delivery of artemether

Cited by 32 publications

References 48 publications

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

Nanostructured Lipid Carriers for Transdermal Drug Delivery

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

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