Formulation and in vitro Characterization of Time Release Tablets of Propranolol Hydrochloride

Giri, Sagarananda; Mohapatra, Sharmistha

doi:10.36468/pharmaceutical-sciences.641

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…When considering patient-doctor relationship as one crucial foundation of patient retention, PPV highlighted the quality of medical information sharing and patientdoctor communication [20,[23][24][25][26]. Patients gave a high value to an adequate communication which emphasized a shared decision-making model between doctors and patients [10].…”

Section: Literature Reviewmentioning

confidence: 99%

Empirical Investigation on the Characteristics and Perceived Value of Patients in Medical Treatment Seeking: In-Depth Research in Zhejiang Province of China

Qian

Zhang

2021

BioMed Research International

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Background. Patient Perceived Value (PPV) provides a valuable perspective to explain why the government reforms on health system in terms of functional medical treatment performance improvement did not decrease the crowded waiting line or increased patient satisfaction in China. Methods. Questionnaires comprising seven constructs were sent to patients from seven highly recognized hospitals in Zhejiang Province of China. It was collected via face-by-face in a twelve-month period (2019), and 2586 valid data were collected for SPSS statistic accordingly. Results. Besides the significance of the functional medical treatment values (such as the treatment effectiveness, accurate price, standardization, and normalization), the emotional values (reasonable waiting time, convenient accessibility, communication with doctors/nurses) were significant in patients’ consciousness. Patient medical treatment seeking preferences were affected by patients’ background characteristics and perceived value, which consequently produced differentiated patients’ satisfaction. Patients’ characteristics, which related to the age, gender, illness conditions, educational, and income level, would have different demanding in medical treatment seeking. These young female patients in outpatient or in mild illness conditions with higher educational and income levels tend to be relatively high in timing and convenience demanding. Conclusion. This result would change the policy maker and hospitals to considerate the patients’ emotional value as well as functional value in providing medical treatment. Classified patients’ time arrangement tactics consistent with distinguished characteristics, equipped up with convenient accessibility and interconnected medical treatment environment design, can create valuable patients’ satisfaction in China.

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Section: Literature Reviewmentioning

confidence: 99%

Empirical Investigation on the Characteristics and Perceived Value of Patients in Medical Treatment Seeking: In-Depth Research in Zhejiang Province of China

Qian

Zhang

2021

BioMed Research International

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“…Stability Study of the Optimized Hydrogel Matrix Formulation: 22,[26][27][28] Stability testing of the optimized formulation was done according to ICH guidelines to assess the stability of the formulation. As per ICH guidelines of accelerated testing, the formulation was sealed in aluminum packaging and kept in a humidity chamber maintained at 40 ºC temp and 75% RH for 3 months.…”

Section: Fourier Transforms Infra-red Spectroscopymentioning

confidence: 99%

Untitled

2021

IJPSR

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Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix tablets of anti-hypertensive drug, Propranolol HCL were prepared and evaluated. The HPMC was used as a rate retarding polymer, whereas Talc was used as filler, and magnesium stearate was used as a lubricant. The present study results point out that the rate of propranolol HCL release from HPMC matrices is mainly controlled by the drug: HPMC ratio. When the concentration of HPMC was enhanced, the release of the drug from the matrix tablet was retarded. The prepared hydrogel matrix tablets were evaluated for various parameters like Angle of Repose, Bulk Density, Tapped Density, Carr's Index, hardness, friability, uniformity of weight, uniformity of drug content, and disintegration studies. The drug-polymer interaction studies were carried out by FTIR studies where it showed that there was no significant interaction. The in-vitro drug release was carried out for all the formulations, and formulation F1 showed about 96% drug release at 12 h. It was concluded that the hydrogel matrix tablet of Propranolol HCL by using HPMC can be prepared to get the desired release of the drug up to 12 h.

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Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives

Nayak

Bhat

Mehta

et al. 2023

CPD

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The expression “as sure as night follows a day” emulates those certain cycles in the environment that are always stable. Circadian rhythms are a group of processes that occur within the body in synchronisation with the external factors in a 24 h cycle. Changes in lifestyle and work shifts have disrupted these stable rhythms, which is a leading cause of lifestyle diseases. Associations between these biological clocks and diseases are abundant. However, it is also known that certain drugs work more efficiently and have minimum toxicity when given during a particular phase of the circadian cycle. Chronotherapeutics focuses on treating diseases according to the endogenous processes which mediate xenobiotic metabolism and drug response at a cellular level. Therefore, treatment of those diseases that show aggravation of symptoms according to the circadian rhythms at a particular time is highly beneficial by chronotherapy. In this article, we have emphasised how the changes in rhythms caused diseases and how chronotherapeutic approaches such as controlled drug release technologies can be a better option for these circadian manipulations that seem to influence all types of disease conditions.

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Formulation and in vitro Characterization of Time Release Tablets of Propranolol Hydrochloride

Cited by 5 publications

References 15 publications

Empirical Investigation on the Characteristics and Perceived Value of Patients in Medical Treatment Seeking: In-Depth Research in Zhejiang Province of China

Empirical Investigation on the Characteristics and Perceived Value of Patients in Medical Treatment Seeking: In-Depth Research in Zhejiang Province of China

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Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives

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