Formulation and in Vitro Evaluation of Lovastatin Buccal Tablets

Abstract

The present investigation is concerned with formulation and in-vitro evaluation of mucoadhesive buccal tablets containing anticholesteremic agent. Lovastatin to by-pass the first pass effect and to improve its bio availability with reduction in dosing frequency. The tablets were prepared by direct compression method. Fifteen formulations were developed with varying combinations of polymers like hydroxy propyl methyl cellulose (HPMC) K100M, Poly vinyl pyrrolidine (PVP) k30, Carbopol 934, Sodium carboxy methyl cellulose. The tablets were tested for weight variation, hardness, drug Content, swelling index and in-vitro drug dissolution study. FTIR studies showed no evidence on interactions between drug, polymers, and excipients. The in-vitro release of Lovastatin was performed under sink conditions (Sodium lauryl sulphate (SLS) PH 6.8, 37 ± 0.5ºC, rpm 50) using USP type II rotating paddle method. The best in-vitro drug release profile was achieved with the formulation F5 which contains HPMC 25 mg, CP 12.5 mg and PVP 12.5 mg. The swelling index of formulation F5 was found to be 6.56 and 78.6 respectively. The formulation F5, containing 20 mg of Lovastatin exhibited 12 h sustained drug release i.e. 98.6 % with desired therapeutic concentration.

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study

“…Formulated films were transparent and evenly thick with no signs of drug or polymer deposition. Rao et al formulated buccal films of zolmitriptan, and it was evident from the work that the weight of the films was directly proportional to the number of excipients and drugs used [48,49]. Similar outcomes were observed in the current work, as the concentrations of the contents of the film also increase the weight of formulated films.…”

“…However, the weight variation between strips of the same formulations was negligible, confirming the suitability of the process. This might be the reason that films have shown uniform drug contents as well [49].…”

Formulation and evaluation of mucoadhesive buccal tablet of Anastrozole

“…Differential Scanning Calorimetry (DSC) studies were done to assure the compatibility of the drug with the primary, secondary polymers, and other additives in the selective formula. DSC is a highly sensitive technique to study the thermotropic properties of drugs [21,22].…”