Formulation and in-Vitro Evaluation of Zolmitriptan in Situ Gel for Nasal Administration

Patil, Payal H.; Belgamwar, Veena S.; Patel, D. A; Surana, Sanjay J.

doi:10.53879/id.50.12.p0054

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The ondansetron HC release from different IG formulas (F1-F6) was shown in figure (5). The IG formulas (F1, F3 and F5) containing 15 % poloxamer-407 showed higher % release after 4 hr than the IG formulas (F2, F4 and F6) containing 20% kolliphore 407, this is because the kolliphore 407 delays the drug release due to the lessening in proportion of water channels resulting for reinforcement micellar structure As the kolliphore 407 consists of very large amount of micelles in aqueous phase, the incorporated drug may be released by diffusion through gel matrix [23] . Drug release can also be affected by the gel viscosity, aqueous channel size, and drug distribution between the micelles and the aqueous phase.…”

Section: Dissolution Releasementioning

confidence: 97%

Effect of different mucoadhesive polymers on release of ondansetron HCl from intranasal mucoadhesive in situ gel

Almajidi

Maraie

2018

AJPS

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The aim of this work was to promote an intranasal mucoadhesive drug allocation system to simplify the systemic delivery of ondansetron HCL (OND-HCl) for the immediate and sustain prevention of repeated nausea and vomiting caused by the initial and repeated courses of anticancer therapy. An in situ gel dosage form was used to raise the permanence time and hence the absorption of OND-HCl from nasal mucosa. Temperature stimulated in situ gel formulations were intended by cold method using polymers like kolliphor 407, chitosan and HPMC E15. A mixture of polysorbate 20 and ethanol (1: 2 ratio) was used as solvent to dissolve the drug. The pH of in situ gel solution was measured to pH range (4.5-6.5). The six in situ gel formulas were characterized for gelation temperature, pH, viscosity, drug content, mucoadhesion and dissolution release .The temperatures of conversion of all the formulas solution to gel were within the range of 30–43ºC. The drug content of all six in situ gel formulas showed drug content uniformity (99.15–99.76%). Dissolution release of the drug from in situ gel formulas showed immediate and sustained release features with Higuchi model and zero order model mechanisms

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Section: Dissolution Releasementioning

confidence: 97%

Effect of different mucoadhesive polymers on release of ondansetron HCl from intranasal mucoadhesive in situ gel

Almajidi

Maraie

2018

AJPS

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“…The effectiveness of using a solubilizer and penetration enhancer for nasal drug administration needs to be proven among the approaches outlined above. 7,8 and β-cyclodextrin were added. 12 After that, the liquid was vigorously stirred until all of the drugs were dissolved.…”

Section: Introductionmentioning

confidence: 99%

Development of Nasal In-situ Gel Formulation of Fexofenadine HCl Using Gellan Gum (Gelerite®)

Amarsing¹,

Pandit²

2023

IJPQA

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This study aimed to develop and assess an in-situ nasal gel containing fexofenadine hydrochloride for nasal administration by employing polymers with in-situ gelling characteristics. Formulations containing Gelerite, HPMC K4M and β-cyclodextrin were used to formulate in situ nasal gel. Formulations were liquid before administration and quickly converted to gel after nasal administration. The FTIR studies of drugs, polymers and physical mixtures of drug polymers were carried out. These research results indicated that, in comparison to pure drugs, there have been no considerable modifi cations in the drug bands. Hence, the FTIR study revealed that the formulation doesn’t have any drug-polymer interaction. In order to estimate rheological studies, a Fungilab Brookfi eld viscometer was used to test the formulation’s viscosity. The ranges of the rheological properties of the solution and gel were shown to be 91 ± 1.73 to 125 ± 0.77 and 2740 ± 1.55 to 4675 ± 1.43, respectively. The gel strength of formulations F1 to F9 was found to be in the range of 34 ± 1.00 to 51.23 ± 1.77 seconds. It was shown that the viscosity of the formulation decreased at increasing shear stress, exhibiting shear thinning behavior. A viscosity of formulation increase was noticed with an increase in polymer ratio. All formulations were subjected to an in-vitro diff usion analysis, which will demonstrate the impact of various factors on the formulation’s ability to release the drugs.

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Gel-based delivery of neurotherapeutics via naso-brain pathways

Mahajan

Patil

2021

Direct Nose-to-Brain Drug Delivery

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Formulation and in-Vitro Evaluation of Zolmitriptan in Situ Gel for Nasal Administration

Cited by 3 publications

References 10 publications

Effect of different mucoadhesive polymers on release of ondansetron HCl from intranasal mucoadhesive in situ gel

Effect of different mucoadhesive polymers on release of ondansetron HCl from intranasal mucoadhesive in situ gel

Development of Nasal In-situ Gel Formulation of Fexofenadine HCl Using Gellan Gum (Gelerite®)

Gel-based delivery of neurotherapeutics via naso-brain pathways

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