Formulation and in-vitro evaluation of moxifloxacin loaded crosslinked chitosan films for the treatment of periodontitis

Chinta, Durga Praveena; Katakam, Prakash; Murthy, Varanasi S N; Newton, Maria J

doi:10.1016/j.jopr.2013.06.019

Cited by 8 publications

(6 citation statements)

References 2 publications

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“…Similar approaches were also investigated by different research teams, which proposed the inclusion of various drugs, both synthetic and natural, i.e., tenoxicam, moxifloxacin, ciprofloxacin, metformin and curcumin, into polymeric film for periodontitis treatment [ 77 , 78 , 79 , 80 , 81 ].…”

Section: Main Scaffolds In Periodontal Tissue Regenerationmentioning

confidence: 99%

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

et al. 2021

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Periodontal diseases are multifactorial disorders, mainly due to severe infections and inflammation which affect the tissues (i.e., gum and dental bone) that support and surround the teeth. These pathologies are characterized by bleeding gums, pain, bad breath and, in more severe forms, can lead to the detachment of gum from teeth, causing their loss. To date it is estimated that severe periodontal diseases affect around 10% of the population worldwide thus making necessary the development of effective treatments able to both reduce the infections and inflammation in injured sites and improve the regeneration of damaged tissues. In this scenario, the use of 3D scaffolds can play a pivotal role by providing an effective platform for drugs, nanosystems, growth factors, stem cells, etc., improving the effectiveness of therapies and reducing their systemic side effects. The aim of this review is to describe the recent progress in periodontal regeneration, highlighting the influence of materials’ properties used to realize three-dimensional (3D)-scaffolds, their bio-physical characteristics and their ability to provide a biocompatible platform able to embed nanosystems.

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Section: Main Scaffolds In Periodontal Tissue Regenerationmentioning

confidence: 99%

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

et al. 2021

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“…A crosslinked film of chitosan with sodium citrate has also been made as a moxifloxacin drug delivery system. Chitosan-citrate cross-linked films were made using the immersion method, which was chitosan films, made from 4% chitosan solution in 4% acetic acid, being soaked with 4% sodium citrate in pH 5 producing good tensile strength and film folding resistance, and good physicochemistry (Chinta et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan-Citrate Microparticle Using Ionic Gelation Methods

Latupeirissa

Tanasale

Fransina

et al. 2022

Indo. J. Chem. Res.

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A study has been conducted aimed to synthesize chitosan-citrate using the ionic gelation method and its characterization with FTIR, SEM, SAA, and PSA, as well as solubility and swelling tests. The results showed that chitosan reacted with sodium citrate producing chitosan-citrate particles. The product of chitosan-citrate has a rough and thickened surface morphology. Surface area is obtained by 35.233 m2/g and pore size is 0.027 cc/g, smaller than chitosan. Based on solubility and swelling tests in acidic, alkaline, and neutral media, chitosan-citrate has good resistance and low swelling effect.

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“…Local application of antibiotics has been advocated for patients with localized lesions or a limited amount of non-responding or recurrent sites [4]. In the literature, many articles are about the development of various types of delivery systems (fibers, films, gels, strips, injectable systems, microparticles) containing different active agents (tetracycline, doxycycline, chlorhexidine, clindamycin, metronidazole, amoxicillin, povidone-iodine) [7,9,10,11,12,13,14,15,16,17,18,19,20,21,22].…”

Section: Introductionmentioning

confidence: 99%

Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis

et al. 2019

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Background: Despite being a highly prevalent disease and a possible contributor to adult tooth loss, periodontitis possesses no well-established therapy. The aim of the recent study was the development and evaluation of a mucoadhesive monophase lipid formulation for the sustained local delivery of amoxicillin, metronidazole, and/or zinc hyaluronate or gluconate. Methods: To investigate our formulations, differential scanning calorimetry, X-ray diffraction, swelling, erosion, mucoadhesivity, drug release, and antimicrobial measurements were performed. Results: Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) results show that the loaded drugs are in a suspended form, the softening of the formulations starts at body temperature, but a part remains solid, providing sustained release. Swelling of the lipid compositions is affected by the hydrophilic components, their concentration, and the strength of the coherent lipid structure, while their erosion is impacted by the emulsification of melted lipid components. Conclusions: Results of drug release and antimicrobial effectiveness measurements show that a sustained release may be obtained. Amoxicillin had higher effectiveness against oral pathogens than metronidazole or zinc hyaluronate alone, but the combination of the two latter could provide similar effectiveness to amoxicillin. The applied mucoadhesive polymer may affect adhesivity, drug release through the swelling mechanism, and antimicrobial effect as well.

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Formulation and in-vitro evaluation of moxifloxacin loaded crosslinked chitosan films for the treatment of periodontitis

Cited by 8 publications

References 2 publications

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

Synthesis and Characterization of Chitosan-Citrate Microparticle Using Ionic Gelation Methods

Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis

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