Formulation and Optimization of Drug-Resin Complex Loaded Mucoadhesive Chitosan Beads of Repaglinide Using Factorial Design

Abstract

Some ion exchange resins like Cholestyramine (Duolite AP-143), provide extended gastric retention and have the ability to coat the gastric mucosa uniformly. The use of such mucoadhesive ion exchange resins is another attractive approach in the development of targeted formulations for the GIT. In pesent work, a mucoadhesive gastroretentive system for Repaglinide was developed and optimized using Duolite AP-143 resin by RSM. Studies were carried out to develop and optimize oral mucoadhesive beads for Repaglinide using ion exchange resin and chitosan. Resinates prepared were studied for the effect of pH and drug resin ratio on drug loading. Resin and resinates were evaluated for mucoadhesive property using falling liquid film method. Resin and resinates showed sufficient mucoadhesion strength when compared with other mucoadhesive polymers and other ion exchange resins. Dissolution study of Repaglinide resinate showed that Duolite AP-143 was able to sustain the release of drug. The study suggests that the mucoadhesive beads of Repaglinide provide sustained release over 8 h and also shows sufficient mucoadhesive strength with rabbit gastric mucosa.

Modification in the Approach of Developing Solid Dispersed Particles for Enhanced Dissolution

“…Similarly, the absence of any characteristic peak of drug in the spectrum of solid dispersion showed the conversion of crystalline drug in its amorphous form which occurs due to its molecular dispersion within the amorphous carrier. 29 This result obtained through X-RD spectrum supports the DSC and FT-IR studies.…”